Volume 8.25 | Jun 30

2020-06-30 | HIN 25
Human Immunology News by STEMCELL Technologies
Vol. 8.25 – 30 June, 2020

IL-18BP Is a Secreted Immune Checkpoint and Barrier to IL-18 Immunotherapy

Researchers showed that IL-18BP, a high-affinity IL-18 decoy receptor, was frequently upregulated in diverse human and mouse tumors and limited the anti-tumor activity of IL-18 in mice.

AbstractPress Release
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Distinct Synovial Tissue Macrophage Subsets Regulate Inflammation and Remission in Rheumatoid Arthritis

Investigators used single-cell transcriptomics to profile 32,000 synovial tissue macrophages and identified phenotypic changes in patients with early/active rheumatoid arthritis (RA), treatment-refractory/active RA and RA in sustained remission.
[Nature Medicine]


The Transcription Factor Hhex Cooperates with the Corepressor Tle3 to Promote Memory B Cell Development

Using single-cell RNA sequencing analysis, the authors identified a population of germinal center B cells in the process of differentiating into memory B cells.
[Nature Immunology]


Metabolic Engineering against the Arginine Microenvironment Enhances CAR-T Cell Proliferation and Therapeutic Activity

Scientists demonstrated T cells could be re-engineered to express functional argininosuccinate synthase or ornithine transcarbamylase enzymes, in concert with different chimeric antigen receptors.


IL10RA Modulates Crizotinib Sensitivity in NPM1-ALK-Positive Anaplastic Large Cell Lymphoma

Through genome-wide CRISPR activation and knockout screens in Anaplastic Lymphoma Kinase (ALCL) cell lines combined with RNA-seq data derived from ALK inhibitor relapsed patient tumors, researchers showed that resistance to ALK inhibition by crizotinib in ALCL could be driven by aberrant upregulation of IL10RA.


Tumor Invasion in Draining Lymph Nodes Is Associated with Treg Accumulation in Breast Cancer Patients

Researchers studied regulatory T cells from matched tumor-invaded and non-invaded tumor-draining lymph node, and breast tumors.
[Nature Communications]

Full Article

PRL3 Enhances T-Cell Acute Lymphoblastic Leukemia Growth through Suppressing T-Cell Signaling Pathways and Apoptosis

Scientists identified protein tyrosine phosphatase type 4 A3 (PRL3) as a collaborating oncogenic driver in T-cell acute lymphoblastic leukemia.


Discovery of CD80 and CD86 as Recent Activation Markers on Regulatory T Cells by Protein-RNA Single-Cell Analysis

The authors quantified the single-cell expression of 397 genes at the mRNA level and up to 68 proteins using oligo-conjugated antibodies in 43,656 primary CD4+ T cells isolated from the blood and 31,907 CD45+ cells isolated from the blood and matched duodenal biopsies.
[Genome Medicine]

Characteristics of Autologous Protein Solution and Leucocyte-Poor Platelet-Rich Plasma for the Treatment of Osteoarthritis of the Knee

Researchers investigated the differences in the humoral factors present in two types of platelet-rich plasma purified using the Autologous Protein Solution kit or the Cellaid Serum Collection Set P type.
[Scientific Reports]

Full Article

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International Consensus on ANCA Testing in Eosinophilic Granulomatosis with Polyangiitis

Investigators present an international consensus on anti-neutrophil cytoplasm antibodies (ANCA) testing in eosinophilic granulomatosis with polyangiitis.
[American Journal of Respiratory and Critical Care Medicine]


Advances and Potential Pitfalls of Oncolytic Viruses Expressing Immunomodulatory Transgene Therapy for Malignant Gliomas

Scientists summarize the research advances related to oncolytic viruses that express immunomodulatory transgenes, as well as potential treatment pitfalls in patients with malignant gliomas.
[Cell Death & Disease]



NIH’s New Sexual-Harassment Rules Are Still Too Weak, Say Critics

On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.
[Nature News]


Graduate Programs Drop GRE after Online Version Raises Concerns about Fairness

Scores of academics have raised concerns about the equity of the online version of the test, arguing it disadvantages prospective students from rural and low-income backgrounds. “If I were … a student trying to take this exam, satisfying criteria would be extremely difficult for me,” says Emily Levesque, an assistant professor of astronomy at the University of Washington, Seattle.


NeoImmuneTech Announces First Patient Dosed in Phase Ib/IIa Study of NT-I7 (Efineptakin Alfa) and KEYTRUDA® (Pembrolizumab) in Patients with Relapsed/Refractory Advanced Solid Tumors

NeoImmuneTech, Inc. announced the first patient has been dosed at The University of Texas MD Anderson Cancer Center in the Phase Ib/IIa clinical trial of NT-I7 in combination with KEYTRUDA®, a leading checkpoint inhibitor, for the treatment of patients with relapsed/refractory advanced solid tumors.
[NeoImmuneTech, Inc.]


2020 Parenteral Drug Association (PDA) Annual Meeting

July 20 – July 22

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Postdoctoral Researcher – Molecular Biology and Immunology

University of California Los Angeles – Los Angeles, California, United States

Research Scientist – SARS-CoV-2 Vaccine Development

Ohio State University – Columbus, Ohio, United States

Postdoctoral Fellow – Immunology

H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States

Postdoctoral Fellow – Immune and Stem Cell Engineering

Terasaki Institute for Biomedical Innovation – Los Angeles, California, United States

Research Scientist – Tumor Immunology

Northwestern University – Chicago, Illinois, United States

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