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Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
Immunotherapy Drives Mesenchymal Tumour Cell State Shift and TME Immune Response in Glioblastoma Patients
[Neuro-Oncology] Investigators present the integrative paired single-cell RNA-seq analysis of 76 tumor samples from patients in a clinical trial of the PD-1 inhibitor nivolumab and untreated patients.
Microbiome Dynamics in Immune Checkpoint Blockade
[Trends In Endocrinology And Metabolism] The authors describe recent findings from clinical trials, observational studies of human patients, and animal studies on the impact of the microbiome on the efficacy of immune checkpoint blockade.
CPT-11 Mitigates Autoimmune Diseases by Suppressing Effector T Cells Without Affecting Long-Term Anti-Tumor Immunity
[Cell Death Discovery] Researchers showed that CPT-11 suppresses T cell proliferation and pro-inflammatory cytokine production in healthy C57BL/6 mice and in complete Freund’s adjuvant-challenged mice.
ScRNA-Seq Reveals Novel Immune-Suppressive T Cells and Investigates CMV-TCR-T Cells Cytotoxicity Against GBM
[Journal For Immunotherapy Of Cancer] Investigators evaluated the cytomegalovirus (CMV) infection status of patients with glioblastoma's (GBM’s) tumor tissue by immune electron microscopy, immunofluorescence, and droplet digital PCR. We performed single-cell RNA sequencing for CMV-infected GBM to investigate the effects of CMV on the GBM immune microenvironment.
Fibrostricturing Crohn’s Disease Is Marked by an Increase in Active Eosinophils in the Deeper Layers
[Clinical And Translational Gastroenterology] This study characterized immune cell distribution and protein expression in fibrotic and inflamed ileal tissue of Crohn's disease patients. Immunologic, proteomic and histological data suggest inflammation and fibrosis were intertwined, with large overlap between both tissue types.
The Effect of T Cell Aging on the Change of Human Tissue Structure
[Immunity & Ageing] The authors discuss the general characteristics of age-related T cell immune alterations and the possible effects of aging T cells in various tissue structures in the human body.
T Cell Characteristics Impact Response and Resistance to T Cell-Redirecting Bispecific Antibodies in Multiple Myeloma
[Clinical Cancer Research] The anti-multiple myeloma (MM) activity of teclistamab and talquetamab was evaluated in bone marrow (BM) samples from MM patients. T cell phenotype and function were assessed in BM/peripheral blood samples obtained from MM patients who were treated with these bispecific antibodies.
Polymer-Based Antibody Mimetics (iBodies) Target Human PD-L1 and Function as a Potent Immune Checkpoint Blocker
[Journal Of Biological Chemistry] Scientists reported the development of polymer-based anti-human PD-L1 antibody mimetics by attaching the macrocyclic peptide WL12 to a N-(2-hydroxypropyl)methacrylamide copolymer.
In Vitro Enhancement of Zika Virus Infection by Preexisting West Nile Virus Antibodies in Human Plasma-Derived Immunoglobulins Revealed After P2 Binding Site-Specific Enrichment
[Microbiology Spectrum] Investigators examined a panel of intravenous immunoglobulins manufactured over the past two decades for their capacity to neutralize or enhance Zika virus infection in vitro.
A Link Between Circulating Immune Complexes and Acute Kidney Injury in Human Visceral Leishmaniasis
[Scientific Reports] Researchers evaluated the involvement of immunoglobulins and immune complexes in the occurrence of acute kidney injury in visceral leishmaniasis (VL) patients. Fourteen VL patients were evaluated between early treatment and 12 months post-treatment.
Development of KoRV-Pseudotyped Lentiviral Vectors for Efficient Gene Transfer Into Freshly Isolated Immune Cells
[Gene Therapy] Koala Retrovirus-based envelope demonstrated remarkable efficiency in transducing freshly isolated primary human NK cells directly from blood, as well as freshly obtained monocytes, which were differentiated to M1 macrophages as well as B cells from multiple donors, achieving up to 80% reporter gene expression within three days post-transduction.
Advancing Immunotherapy Using Biomaterials to Control Tissue, Cellular, and Molecular Level Immune Signaling in Skin
[Advanced Drug Delivery Reviews] The authors highlight recent pre-clinical and clinical advances in biomaterial-based approaches to target and modulate skin immune signaling at the tissue, cellular, and molecular levels for immunotherapeutic applications.
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.
