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Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
Traverse Biotech Awarded Phase I SBIR Grant by the National Institute of Allergy and Infectious Diseases for Development of Innate Immune Stimulator
[Traverse Biotech, Inc. (PR Newswire)] Traverse Biotech, Inc. has been awarded a Phase I Small Business Innovation Research grant from the National Institute of Allergy and Infectious Diseases, part of the NIH.
BTK Drives Neutrophil Activation for Sterilizing Antifungal Immunity
[Journal Of Clinical Investigation] Upon fungal exposure, BTK was activated in human neutrophils in a TLR2-, Dectin-1-, and FcγR-dependent manner, triggering the oxidative burst.
Intravital Imaging of the Human Cornea Reveals the Differential Effects of Season on Innate and Adaptive Immune Cell Morphodynamics
[Ophthalmology] Researchers investigated the effect of seasonal-driven environmental factors on the density, morphology, and dynamic behavior of human corneal immune cell subsets.
Pan-Cancer Analysis of Prognostic and Immunological Role of IL4I1 in Human Tumors: A Bulk Omics Research and Single Cell Sequencing Validation
[Discover Oncology] IL4I1 was significantly overexpressed in the majority of tumors, and the imbalance of IL4I1 was significantly correlated with overall survival and pathological stage. Moreover, total IL4I1 protein was increased in cancer.
T Cell Expression of CXCL13 Is Associated with Immunotherapy Response in a Sex-Dependent Manner in Patients with Lung Cancer
[Cancer Immunology Research] The authors investigated differences in T cell responses between male and female patients with lung cancer by performing sex-based analysis of single cell transcriptomic datasets.
PGRN Is Involved in Macrophage M2 Polarization Regulation through TNFR2 in Periodontitis
[Journal Of Translational Medicine] Immunohistochemical and multiplex immunohistochemical stainings were performed to evaluate the expression of macrophage-related markers and progranulin (PGRN) in gingival samples from periodontally healthy subjects and periodontitis subjects.
Israeli Researchers Measure Interaction Between Immune Cells and Cancer Cells
[The Jerusalem Post] A new technology developed at Bar-Ilan University in Ramat Gan and funded by the Israel Cancer Association will help oncologists and other medical professionals to determine the best way to help patients.
Immunotherapy Drives Mesenchymal Tumor Cell State Shift and TME Immune Response in Glioblastoma Patients
[Neuro-Oncology] Investigators present the integrative paired single-cell RNA-seq analysis of 76 tumor samples from patients in a clinical trial of the PD-1 inhibitor nivolumab and untreated patients.
Microbiome Dynamics in Immune Checkpoint Blockade
[Trends In Endocrinology And Metabolism] The authors describe recent findings from clinical trials, observational studies of human patients, and animal studies on the impact of the microbiome on the efficacy of immune checkpoint blockade.
CPT-11 Mitigates Autoimmune Diseases by Suppressing Effector T Cells Without Affecting Long-Term Anti-Tumor Immunity
[Cell Death Discovery] Researchers showed that CPT-11 suppresses T cell proliferation and pro-inflammatory cytokine production in healthy C57BL/6 mice and in complete Freund’s adjuvant-challenged mice.
Fibrostricturing Crohn’s Disease Is Marked by an Increase in Active Eosinophils in the Deeper Layers
[Clinical And Translational Gastroenterology] This study characterized immune cell distribution and protein expression in fibrotic and inflamed ileal tissue of Crohn's disease patients. Immunologic, proteomic and histological data suggest inflammation and fibrosis were intertwined, with large overlap between both tissue types.
The Effect of T Cell Aging on the Change of Human Tissue Structure
[Immunity & Ageing] The authors discuss the general characteristics of age-related T cell immune alterations and the possible effects of aging T cells in various tissue structures in the human body.
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.
