Human Immunology News

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.

Fibrostricturing Crohn’s Disease Is Marked by an Increase in Active Eosinophils in the Deeper Layers

May 1, 2024

[Clinical And Translational Gastroenterology] This study characterized immune cell distribution and protein expression in fibrotic and inflamed ileal tissue of Crohn's disease patients. Immunologic, proteomic and histological data suggest inflammation and fibrosis were intertwined, with large overlap between both tissue types.

The Effect of T Cell Aging on the Change of Human Tissue Structure

May 1, 2024

[Immunity & Ageing] The authors discuss the general characteristics of age-related T cell immune alterations and the possible effects of aging T cells in various tissue structures in the human body.

T Cell Characteristics Impact Response and Resistance to T Cell-Redirecting Bispecific Antibodies in Multiple Myeloma

April 30, 2024

[Clinical Cancer Research] The anti-multiple myeloma (MM) activity of teclistamab and talquetamab was evaluated in bone marrow (BM) samples from MM patients. T cell phenotype and function were assessed in BM/peripheral blood samples obtained from MM patients who were treated with these bispecific antibodies.

Polymer-Based Antibody Mimetics (iBodies) Target Human PD-L1 and Function as a Potent Immune Checkpoint Blocker

April 30, 2024

[Journal Of Biological Chemistry] Scientists reported the development of polymer-based anti-human PD-L1 antibody mimetics by attaching the macrocyclic peptide WL12 to a N-(2-hydroxypropyl)methacrylamide copolymer.

In Vitro Enhancement of Zika Virus Infection by Preexisting West Nile Virus Antibodies in Human Plasma-Derived Immunoglobulins Revealed After P2 Binding Site-Specific Enrichment

April 30, 2024

[Microbiology Spectrum] Investigators examined a panel of intravenous immunoglobulins manufactured over the past two decades for their capacity to neutralize or enhance Zika virus infection in vitro.

A Link Between Circulating Immune Complexes and Acute Kidney Injury in Human Visceral Leishmaniasis

April 30, 2024

[Scientific Reports] Researchers evaluated the involvement of immunoglobulins and immune complexes in the occurrence of acute kidney injury in visceral leishmaniasis (VL) patients. Fourteen VL patients were evaluated between early treatment and 12 months post-treatment.

Development of KoRV-Pseudotyped Lentiviral Vectors for Efficient Gene Transfer Into Freshly Isolated Immune Cells

April 30, 2024

[Gene Therapy] Koala Retrovirus-based envelope demonstrated remarkable efficiency in transducing freshly isolated primary human NK cells directly from blood, as well as freshly obtained monocytes, which were differentiated to M1 macrophages as well as B cells from multiple donors, achieving up to 80% reporter gene expression within three days post-transduction.

Advancing Immunotherapy Using Biomaterials to Control Tissue, Cellular, and Molecular Level Immune Signaling in Skin

April 30, 2024

[Advanced Drug Delivery Reviews] The authors highlight recent pre-clinical and clinical advances in biomaterial-based approaches to target and modulate skin immune signaling at the tissue, cellular, and molecular levels for immunotherapeutic applications.

U.S. Commercialization Agreement with Quallent to Drive Patient Savings with First High-Concentration Citrate-Free Interchangeable Biosimilar to Humira® (adalimumab)

April 30, 2024

[Alvotech] Alvotech disclosed that under the recently announced US strategic partnership agreement, Alvotech will manufacture its high-concentration interchangeable biosimilar to Humira® for Quallent Pharmaceuticals, in alignment with its US commercialization agreement with Teva.

Development of a Compact Bidirectional Promoter-Driven Dual Chimeric Antigen Receptor (CAR) Construct Targeting CD19 and CD20 in the Sleeping Beauty (SB) Transposon System

April 29, 2024

[Journal Of Immunotherapy of Cancer] Scientists developed a second-generation CAR directing CD19 and CD20 antigens, incorporating them in a head-to-head orientation from a bidirectional promoter using a single Sleeping Beauty transposon system. The efficacy of bidirectional promoter-driven dual CD19 and CD20 CAR T cells was determined in vitro against cell lines expressing either, or both, CD19 and CD20 antigens.

Hyper-N-Glycosylated SEL1L3 as Auto-Antigenic B-Cell Receptor Target of Primary Vitreoretinal Lymphomas

April 29, 2024

[Scientific Reports] To investigate the role of chronic antigenic stimulation in primary vitreoretinal lymphoma (PVRL), scientists cloned and expressed B-cell receptors from PVRL patients and tested for binding against human auto-antigens.

TYM-3-98, a Novel Selective Inhibitor of PI3Kδ, Demonstrates Promising Preclinical Antitumor Activity in B-Cell Lymphomas

April 29, 2024

[Life Sciences] In vivo, TYM-3-98 showed good pharmaceutical properties and remarkably reduced tumor growth in a human lymphoma xenograft model and a mouse lymphoma model.

Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.