Human Immunology News

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.

Development of a Compact Bidirectional Promoter-Driven Dual Chimeric Antigen Receptor (CAR) Construct Targeting CD19 and CD20 in the Sleeping Beauty (SB) Transposon System

April 29, 2024

[Journal Of Immunotherapy of Cancer] Scientists developed a second-generation CAR directing CD19 and CD20 antigens, incorporating them in a head-to-head orientation from a bidirectional promoter using a single Sleeping Beauty transposon system. The efficacy of bidirectional promoter-driven dual CD19 and CD20 CAR T cells was determined in vitro against cell lines expressing either, or both, CD19 and CD20 antigens.

Hyper-N-Glycosylated SEL1L3 as Auto-Antigenic B-Cell Receptor Target of Primary Vitreoretinal Lymphomas

April 29, 2024

[Scientific Reports] To investigate the role of chronic antigenic stimulation in primary vitreoretinal lymphoma (PVRL), scientists cloned and expressed B-cell receptors from PVRL patients and tested for binding against human auto-antigens.

TYM-3-98, a Novel Selective Inhibitor of PI3Kδ, Demonstrates Promising Preclinical Antitumor Activity in B-Cell Lymphomas

April 29, 2024

[Life Sciences] In vivo, TYM-3-98 showed good pharmaceutical properties and remarkably reduced tumor growth in a human lymphoma xenograft model and a mouse lymphoma model.

PolyU Collaborates With Axis Therapeutics to Establish Joint Laboratory for Immunotherapy

April 29, 2024

[Hong Kong Polytechnic University (EurekAlert!)] The Hong Kong Polytechnic University has entered into a formal collaboration with Axis Therapeutics to foster cancer immunotherapy research and development, with the aim of improving cancer treatment for patients in Hong Kong.

Lkb1 Orchestrates γδ T-cell Metabolic and Functional Fitness to Control IL-17-Mediated Autoimmune Hepatitis

April 24, 2024

[Cellular & Molecular Immunology] Researchers investigated the role of liver kinase B1 (Lkb1), a serine/threonine kinase that links cellular metabolism with cell growth and proliferation, in γδ T-cell biology.

Integrating Multisector Molecular Characterization into Personalized Peptide Vaccine Design for Patients with Newly Diagnosed Glioblastoma

April 23, 2024

Researchers demonstrated the feasibility of incorporating multisector sampling in cancer vaccine design and provided information on the clinical applicability of clonality, distribution, and immunogenicity...

Anti-Tumor Activity of a Novel LAIR1 Antagonist in Combination with Anti-PD-1 to Treat Collagen-Rich Solid Tumors

April 23, 2024

[Molecular Cancer Therapeutics] Investigators reported leukocyte-associated immunoglobulin-like receptor 1 was associated with tumor stroma and was highly expressed by intratumoral myeloid cells in both human tumors and mouse models of cancer.

Lactobacillus reuteri Vesicles Regulate Mitochondrial Function of Macrophages to Promote Mucosal and Cutaneous Wound Healing

April 23, 2024

[Advanced Science] Researchers revealed, for the initial time, the significant enhancement of mucosal and cutaneous wound healing by membrane vesicles secreted by the human commensal Lactobacillus reuteri through modulation of the inflammatory environment in wound tissue.

The CD318/CD6 Axis Limits Type 1 Diabetes Islet Autoantigen-Specific Human T Cell Activation

April 23, 2024

[Journal Of Autoimmunity] Scientists reported CD318 expression in a subpopulation of CD318+ myeloid dendritic, whereas the other peripheral blood populations were CD318 negative.

HERV-W Upregulation Expression in Bipolar Disorder and Schizophrenia: Unraveling Potential Links to Systemic Immune/Inflammation Status

April 23, 2024

[Retrovirology] Investigators assessed the level of human endogenous retrovirus W (HERV-W)-env expression and the systemic inflammatory profile through the concentration of IL-2, IL-4, IL-6, IL-10, TNF-α and INF-γ cytokines in bipolar disorder and schizophrenia patients.

HLA Reduction of Human T Cells Facilitates Generation of Immunologically Multi-compatible Cellular Products

April 23, 2024

[Blood Advances] Researchers showed that human leukocyte antigen knockout (HLA KO) does not alter T-cell functionality in vitro and in vivo. While HLA KO abrogated allogeneic T-cell responses, it elicited NK-cell recognition. To circumvent this problem, they demonstrated that selective editing of individual HLA class I molecules in primary human T cells was possible.

Bone Marrow CD8+ Trm Cells Induced by IL-15 and CD16+ Monocytes Contribute to HSPC Destruction in Human Severe Aplastic Anemia

April 23, 2024

[Clinical Immunology] Scientists performed single-cell RNA sequencing of peripheral blood and bone marrows and bone marrow mononuclear cells from severe aplastic anemia patients and healthy donors and identified a CD8+ T cell subset with a tissue residency phenotype (Trm) in bone marrow that exhibited high IFN-γ and FasL expression and have a higher ability to induce apoptosis in hematopoietic stem and progenitor cells in vitro through FasL expression.

Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.