Volume 8.35 | Jul 7

HIn 8.26 | Jul 7
Human Immunology News by STEMCELL Technologies
Vol. 8.26 – 07 July, 2020
TOP STORY

Dynamics in Protein Translation Sustaining T Cell Preparedness

Scientists investigated the dynamics of mRNA translation kinetics and protein turnover in human naive and activated T cells.
[Nature Immunology]

Abstract
Use ImmunoCult™ to differentiate mouse CD4+ cells to Tregs.
PUBLICATIONSRanked by the impact factor of the journal

Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells

Researchers identified circulating CD88CD1c+CD163+ denritic cells (DCs) as immediate precursors of inflammatory CD88CD14+CD1c+CD163+FcεRI+ DCs.
[Immunity]

Full ArticleGraphical Abstract

Eosinophils Regulate Adipose Tissue Inflammation and Sustain Physical and Immunological Fitness in Old Age

The authors showed that adipose tissue eosinophils undergo major age-related changes in distribution and function associated with impaired adipose tissue homeostasis and systemic low-grade inflammation in both humans and mice.
[Nature Metabolism]

Abstract

Engineering Monocyte/Macrophage-Specific Glucocerebrosidase Expression in Human Hematopoietic Stem Cells Using Genome Editing

The authors report an efficient CRISPR/Cas9-based approach that targeted glucocerebrosidase expression cassettes with a monocyte/macrophage-specific element to the CCR5 safe-harbor locus in human hematopoietic stem and progenitor cells.
[Nature Communications]

Full Article

Xenogenization of Tumor Cells by Fusogenic Exosomes in Tumor Microenvironment Ignites and Propagates Antitumor Immunity

Researchers suggested a previously unidentified method for xenogenizing tumors by using fusogenic exosomes to introduce fusogenic viral antigens onto the tumor cell surface.
[Science Advances]

Full Article

Identification of Human CD4+ T Cell Populations with Distinct Antitumor Activity

Of clinical importance, CD26high and TH17 cells engineered with a chimeric antigen receptor regressed large human tumors to a greater extent than enriched TH1 or TH2 cells.
[Science Advances]

Full Article

Longevity and Replenishment of Human Liver-Resident Memory T Cells and Mononuclear Phagocytes

Allografts were rapidly infiltrated by recipient leukocytes, which recapitulated the liver myeloid and lymphoid composition, and underwent partial reprogramming with acquisition of CD68/CD206 on MNPs and CD69/CD103 on T cells.
[Journal of Experimental Medicine]

AbstractGraphical Abstract

Preclinical Evaluation of CD8+ Anti-BCMA mRNA CAR T Cells for Treatment of Multiple Myeloma

Scientists developed a novel CD8+ CAR T-cell product, Descartes-08, with predictable pharmacokinetics for treatment of multiple myeloma. Descartes-08 was engineered by mRNA transfection to express anti-BCMA CAR for a defined length of time.
[Leukemia]

Abstract

ERMAP Is a B7 Family-Related Molecule That Negatively Regulates T Cell and Macrophage Responses

Researchers identified erythroid membrane-associated protein (ERMAP) as a novel T cell inhibitory molecule. ERMAP shared significant sequence and structural homology with existing B7 family members in its extracellular domain.
[Cellular & Molecular Immunology]

Abstract

Fewer Tumor-Specific PD-1+CD8+ TILs in High-Risk “Infiltrating” HPV− HNSCC

The tumor and TIL phenotypic characteristics of 134 HNSCC specimens were retrospectively analysed. HNSCC data from the Cancer Genome Atlas were analysed for CD8α, HPV and overall survival.
[British Journal of Cancer]

Abstract

CXCL5 Promotes Gastric Cancer Metastasis by Inducing Epithelial-Mesenchymal Transition and Activating Neutrophils

The authors report that the expression of CXCL5 was elevated in tumor tissues and positively associated with lymphatic metastasis and tumor differentiation.
[Oncogenesis]

Full Article

A Novel Humanized Mouse Model to Study the Function of Human Cutaneous Memory T Cells In Vivo in Human Skin

Scientists utilized immunodeficient NOD-scid IL2rγnull (NSG) mice that carried in vivo-generated engineered human skin (ES). ES was generated from human keratinocytes and fibroblasts and was initially devoid of skin-resident immune cells.
[Scientific Reports]

Full Article

Scientific resources to support your cell therapy research. Learn More!
REVIEWS

Metabolism of Immune Cells in Cancer

Through the successes of checkpoint blockade and adoptive cellular therapy, immunotherapy has become an established treatment modality for cancer.
[Nature Reviews Cancer]

Abstract

T Cell Antigen Discovery

The T cell receptors–peptide-MHC interaction mediates’ between a T cell and its target cell dictates its function and thereby influences its role in disease.
[Nature Metabolism]

Abstract

Fc Gamma Receptors and Their Role in Antigen Uptake, Presentation, and T Cell Activation

Investigators cover the contribution of FcγRs to antigen-presentation with a focus on the intracellular trafficking of IgG-immune complexes and the pathways that support this function.
[Frontiers in Immunology]

Full Article

INDUSTRY AND POLICY NEWS

Cabaletta Bio and Artisan Bio Announce Gene Editing Research and Collaboration Agreement to Develop Next-Generation CAAR T Cell Therapies

Cabaletta Bio, Inc. announced they have signed a research and collaboration agreement to accelerate development of next-generation CAAR T cell therapies for patients with B cell-mediated autoimmune diseases.
[Calbetta Bio, Inc.]

Press Release

Initiative Recruits Scientist-Volunteers to Aid COVID-19 Research

In mid-March, as businesses and universities across Europe were shutting down in a bid to slow the COVID-19 pandemic, three longtime friends were talking about how they wished they could do something to combat the disease.
[The Scientist]

Editorial

FEATURED EVENT

Keystone eSymposia | Advances in Cancer Immunotherapy

August 17 – August 19
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JOB OPPORTUNITIES

Program Head – Cell Therapy and Immuno-Oncology Development

Lerner Research Institute – Cleveland, Ohio, United States

Postdoctoral Researcher – Molecular Biology and Immunology

University of California Los Angeles – Los Angeles, California, United States

Research Scientist – SARS-CoV-2 Vaccine Development

Ohio State University – Columbus, Ohio, United States

Postdoctoral Fellow – Immunology

H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States

Postdoctoral Fellow – Immune and Stem Cell Engineering

Terasaki Institute for Biomedical Innovation – Los Angeles, California, United States

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