Human Immunology News

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.

Type I Interferon Regulates Interleukin-1beta and IL-18 Production and Secretion in Human Macrophages

[Life Science Alliance] To investigate the effect of type I IFN on the inflammasome, scientists treated human monocyte-derived macrophages with IFN-α and observed an increase in CASP1 and GSDMD mRNA levels over time, whereas IL1B and NLRP3 were not directly correlated to IFN-α exposure time.

Prevalence of Apical Periodontitis in Patients with Autoimmune Liver Diseases Under Immune Suppressants and Immune Modulators: A Cross-Sectional Study

[Journal Of Endodontics] Researchers evaluated the prevalence of apical periodontitis in patients suffering from autoimmune liver diseases, in treatment with the immune-suppressants glucocorticoids, azathioprine, and/or ursodeoxycholic acid.

IFN-λ Drives Distinct Lung Immune Landscape Changes and Antiviral Responses in Human Metapneumovirus Infection

[mBio] Scientists showed that type III interferon (IFN-λ) was highly upregulated during human metapneumovirus infection in vitro in human and mouse airway epithelial cells and in vivo in mice. They found through several immunological and molecular assays that type II alveolar cells are the primary producers of IFN-λ.

Public Health Risks of PFAS-Related Immunotoxicity Are Real

[Current Environmental Health Reports] The authors discuss the use of per- and polyfluoroalkyl substances (PFAS) immunotoxicity data in regulatory and clinical decision-making contexts and question whether recent efforts adequately account for PFAS immunotoxicity in public health decision-making.

Expression of USP25 Associates with Fibrosis, Inflammation and Metabolism Changes in IgG4-Related Disease

[Nature Communications] By using IgG4-RD patient peripheral blood mononuclear cells (PBMCs), IgG4-RD cell lines, and Usp25 knockout mice, investigators showed that ubiquitin-specific protease 25 (USP25) engages in multiple pathways to regulate fibrotic and inflammatory pathways that are characteristic to IgG4-RD.

Mpox-Specific Immune Responses Elicited by Vaccination or Infection in People Living with HIV

[Journal Of Infectious Diseases] Investigators improved their understanding of smallpox vaccination-mediated cross-reactivity to other orthopox viruses, and the long-lasting durability of childhood smallpox vaccination-mediated immune responses including in people living with HIV.

Monocyte-Mediated Thrombosis Linked to Circulating Tissue Factor and Immune Paralysis in COVID-19

[Arteriosclerosis Thrombosis And Vascular Biology] Researchers used systems biology approaches including proteomics, transcriptomics, and mass cytometry to define the circulating proteome and circulating immune cell phenotypes in subjects with COVID-19.

Eledon Pharmaceuticals Announces Use of Tegoprubart in First-ever Transplant of Genetically Modified Kidney from a Pig to a Human

[Eledon Pharmaceuticals, Inc.] Eledon Pharmaceuticals, Inc. announced that the company’s investigational anti-CD40L antibody, was used as a component of the immunosuppressive treatment regimen following the first-ever transplant of a kidney from a genetically modified pig to a human.

Mpox-Specific Immune Responses Elicited by Vaccination or Infection in People Living with HIV

[Journal Of Infectious Diseases] Investigators improved their understanding of smallpox vaccination-mediated cross-reactivity to other orthopox viruses, and the long-lasting durability of childhood smallpox vaccination-mediated immune responses including in people living with HIV.

Monocyte-Mediated Thrombosis Linked to Circulating Tissue Factor and Immune Paralysis in COVID-19

[Arteriosclerosis Thrombosis And Vascular Biology] Researchers used systems biology approaches including proteomics, transcriptomics, and mass cytometry to define the circulating proteome and circulating immune cell phenotypes in subjects with COVID-19.

Human Platelet Lysate Enhances In Vivo Activity of CAR-Vδ2 T Cells by Reducing Cellular Senescence and Apoptosis

[Cytotherapy] Scientists sought to enhance the in vivo longevity of CAR-Vδ2 T cells by modulating ex vivo manufacturing conditions and selecting an optimal CAR costimulatory domain.

High-Multiplex Single-Cell Imaging Analysis Reveals Tumor Immune Contexture Associated with Clinical Outcomes After CAR T-cell Therapy

Researchers designed a highly multiplexed imaging mass cytometry panel to simultaneously quantify 31 biomarkers from 13 patients with relapsed/refractory DLBCL who received CAR19/22 T...

Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.

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