|PUBLICATIONS (Ranked by impact factor of the journal)|
Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia|
Scientists report on 16 patients with relapsed or refractory B cell acute lymphoblastic leukemia that they treated with autologous T cells expressing the 19-28z chimeric antigen receptor (CAR) specific to the CD19 antigen. [Sci Transl Med]
Abstract | Press Release
Circulating Giant Macrophages as a Potential Biomarker of Solid Tumors
Using precision microfilters under low-flow conditions, investigators isolated circulating cancer-associated macrophage-like cells (CAMLs) from the peripheral blood of patients with breast, pancreatic, or prostate cancer. CAMLs, which are not found in healthy individuals, were found to express epithelial, monocytic, and endothelial protein markers and were observed bound to circulating tumor cells in circulation. [Proc Natl Acad Sci USA]
Decreased Expression of miR-146a and miR-155 Contributes to an Abnormal Treg Phenotype in Patients with Rheumatoid Arthritis
Scientists investigated microRNA (miR)-146a and miR-155 expression in regulatory T cells (Tregs) of patients with rheumatoid arthritis and their possible impact on Treg function and disease activity. [Ann Rheum Dis]
IL-27 in Human Secondary Lymphoid Organs Attracts Myeloid Dendritic Cells and Impairs HLA Class I-Restricted Antigen Presentation
Findings highlight novel mechanisms underlying the immunosuppressive activity of IL-27, suggesting that this cytokine may function as a homeostatic cytokine in secondary lymphoid organs by limiting duration and/or intensity of ongoing adaptive immune responses. [J Immunol]
Expression of B7-H3, a Potential Factor of Tumor Immune Evasion in Combination with the Number of Regulatory T Cells, Affects against Recurrence-Free Survival in Breast Cancer Patients
Investigators demonstrated that expression of B7-H3 on tumor cells and the number of regulatory T cells in the tumor microenvironment independently affected prognosis in breast cancer patients. [Ann Surg Oncol]
Angiopoietin-1 Upregulates De Novo Expression of Interleukin (Il)-1β and Il1-Ra, and the Exclusive Release of Il1-Ra from Human Neutrophils
Scientists hypothesized that angiopoietin (Ang)1 and Ang2 could modulate inflammatory signals in neutrophils, a possibility they explored through a gene-based assay looking at changes in the mRNA expression of 84 inflammatory cytokines and their receptors. [PLoS One]
Donor-Derived CD4+/CCR7+ T-Cell Partial Selective Depletion Does Not Alter Acquired Anti-Infective Immunity
The authors investigated in vitro the impact of partially selective CD4+/chemokine receptor 7 (CCR7)+ T lymphocytes on acquired anti-infective immune response in ten donors who underwent G-CSF-primed PBSC collection. [Bone Marrow Transpl]
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Challenges and Responses in Human Vaccine Development|
Reverse and structural vaccinology have revealed novel antigen candidates and molecular immunology has led to the formulation of promising adjuvants. Gene expression profiles and immune parameters in patients, vaccinees and healthy controls have formed the basis for biosignatures that will provide guidelines for future vaccine design. [Curr Opin Immunol]
Manipulating Immune Cells for Adoptive Immunotherapy of Cancer
The authors present a brief overview of T cell adoptive cell transfer followed by a review of approaches using alternate lymphocyte subsets and other leukocytes including neutrophils, macrophages and eosinophils. [Curr Opin Immunol]
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