Volume 8.24 | Jun 23

2020-06-23 | HIN 8.24
Human Immunology News by STEMCELL Technologies
Vol. 8.24 – 23 June, 2020

Phase I Trial of First-in-Class ATR Inhibitor M6620 (VX-970) as Monotherapy or in Combination with Carboplatin in Patients with Advanced Solid Tumors

This Phase I trial assessed the ATR inhibitor M6620 as monotherapy and combined with carboplatin. Primary objectives were safety, tolerability, and maximum tolerated dose.
[Journal of Clinical Oncology]

Full Article

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Microglia Promote Glioblastoma via mTOR-Mediated Immunosuppression of the Tumor Microenvironment

Investigators showed that glioblastoma (GBM)‐initiating cells induced mTOR signaling in the microglia but not bone marrow‐derived macrophages in both in vitro and in vivo GBM mouse models.
[EMBO Journal]

Full Article Graphical Abstract

Circulating Immune Cell Phenotype Dynamics Reflect the Strength of Tumor–Immune Cell Interactions in Patients during Immunotherapy

Using an ecological population model, fitted to clinical tumor burden and immune cell abundance data from each patient, scientists found evidence of a strong tumor-circulating immune cell interaction in responder patients but not in those patients that progress on treatment.
[Proceedings of the National Academy of Sciences of the United States of America]


Human Gingiva-Derived Mesenchymal Stem Cells Are Therapeutic in Lupus Nephritis through Targeting of CD39−CD73 Signaling Pathway

Gingiva derived-mesenchymal stem cells limited the development of autoantibodies as well as proteinuria, decreases the frequency of plasma cells and lupus nephritis histopathological scores by directly suppressing B cells activation, proliferation and differentiation.
[Journal of Autoimmunity]


BCALM (AC099524.1) Is a Human B Lymphocyte-Specific Long Noncoding RNA That Modulates B Cell Receptor–Mediated Calcium Signaling

lncRNA interactome, RNA immunoprecipitation, and coimmunoprecipitation studies identified BCR-mediated Ca+ signaling (BCALM)-interacting proteins in B cells, including phospholipase D 1, and kinase adaptor proteins AKAP9 and AKAP13.
[Journal of Immunology]


Identification of Novel Genes Associated with Dysregulation of B Cells in Patients with Primary Sjögren’s Syndrome

The authors identified the molecular mechanism of dysregulation of B cell subpopulations of primary Sjögren’s syndrome at the transcriptome level.
[Arthritis Research & Therapy]

Full Article

Difference in Presence and Number of CD83+ Dendritic Cells in Patients with Ulcerative Colitis and Crohn’s Disease

There were 154 subjects included in this study: 60 with ulcerative colitis, 19 with Crohn’s disease and 75 in the control group. Colonic biopsy was performed in all subjects. Specimens were incubated with a primary anti-CD83 antibody.
[Scientific Reports]

Full Article

Evidence for a Role of RUNX1 as Recombinase Cofactor for TCRβ Rearrangements and Pathological Deletions in ETV6-RUNX1 ALL

Scientists employed a RUNX1 knock-out mouse model and demonstrated by deep TCRβ sequencing, immunostaining and chromatin immunoprecipitation that RUNX1 binds to the initiation site of TCRβ rearrangement and its homozygous inactivation induced severe structural changes of the rearranged TCRβ gene, whereas heterozygous inactivation had almost no impact.
[Scientific Reports]


Analysis of Ex Vivo Expanded and Activated Clinical-Grade Human NK Cells after Cryopreservation

Researchers evaluated activity of fresh and cryopreserved/thawed expanded and activated NK cells generated by interleukin (IL)-15, IL-2 and CD137L expansion.


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Development of CAR-T Cell Therapies for Multiple Myeloma

Main challenges to CAR-T cell therapy will be highlighted as well as strategies to structurally improve the CAR-T cell product, and thereby its efficacy and safety.


Analysis of Ex Vivo Expanded and Activated Clinical-Grade Human NK Cells after Cryopreservation

Scientists evaluated activity of fresh and C/T EA NK cells generated by interleukin (IL)-15, IL-2 and CD137L expansion.



Trump to Suspend New Visas for Foreign Scholars

With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science.
[Nature News]


Arcutis Enrolls Last Patient in Phase II Proof of Concept Clinical Trial Evaluating ARQ-154 (Topical Roflumilast Foam) as a Potential Treatment for Seborrheic Dermatitis

Arcutis Biotherapeutics, Inc. announced it had completed enrollment of its Phase II proof of concept clinical trial evaluating roflumilast foam as a potential treatment for seborrheic dermatitis.
[Arcutis Biotherapeutics, Inc.]

Press Release

Virtual Lab Tours for Recruitment and Outreach

Virtual lab tours are not new, but they have never been as common as in-person lab tours. However, the pandemic has generated strong incentives for formerly in-person lab tours to go online.
[The Scientist]



Allergy and Clinical Immunology Update 2020 – Save the Date!

2020-09-26 – 2020-09-26

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Research Scientist – SARS-CoV-2 Vaccine Development

Ohio State University – Columbus, Ohio, United States

Postdoctoral Fellow – Immunology

H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States

Postdoctoral Fellow – Immune and Stem Cell Engineering

Terasaki Institute for Biomedical Innovation – Los Angeles, California, United States

Research Scientist – Tumor Immunology

Northwestern University – Chicago, Illinois, United States

Technician – Cell Screening and Assay Development

AbCellera Biologics, Inc. – Vancouver, British Columbia, Canada

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