Volume 4.19 | May 17

Human Immunology News 4.19 May 17, 2016
Human Immunology News
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MEK and PI3K-AKT Inhibitors Synergistically Block Activated IL7 Receptor Signaling in T-Cell Acute Lymphoblastic Leukemia
Researchers showed that inhibiting both the MEK and PI3K-AKT pathways synergistically prevents the proliferation of BaF3 cells expressing mutant IL7Ra, JAK and RAS. [Leukemia] Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
Impaired NK-Mediated Regulation of T-Cell Activity in Multiple Sclerosis Is Reconstituted by IL-2 Receptor Modulation
Investigating the peripheral blood and cerebrospinal fluid of multiple sclerosis (MS) patients treated with natalizumab revealed that transmigration of this subset depends on the α4β1 integrin very late antigen-4. Although no MS-related changes in the migratory capacity of natural killer (NK) cells were observed, NK cells derived from patients with MS exhibit a reduced cytolytic activity in response to antigen-activated CD4+ T cells. [Proc Natl Acad Sci USA] Abstract

The Adhesion G Protein-Coupled Receptor GPR56/ADGRG1 Is an Inhibitory Receptor on Human NK Cells
Investigators explored the regulation and function of GPR56/ADGRG1, an adhesion G protein-coupled receptor implicated in developmental processes and expressed distinctively in mature natural killer (NK) cells. [Cell Rep] Full Article | Graphical Abstract

Human Macrophages Induce CD4+Foxp3+ Regulatory T Cells via Binding and Re-Release of TGF-β
As a prerequisite for eventual translation of immunosuppressive macrophage (M2) therapy into clinical settings the authors studied the induction, stability and mechanism of generation of human induced Tregs by M2 macrophages generated with interleukin-4/interleukin-10/transforming growth factor-β (TGF-β). [Immunol Cell Biol] Abstract

BCR–ABL-Specific CD4+ T-Helper Cells Promote the Priming of Antigen-Specific Cytotoxic T Cells via Dendritic Cells
Scientists established a BCR–ABL p210 b3a2 fusion-region-specific CD4+ T-helper-cell clone and examined its dendritic cell-mediated antileukemic potential. [Cell Mol Immunol] Abstract

Redirecting T-Cell Specificity to EGFR Using mRNA to Self-Limit Expression of Chimeric Antigen Receptor
Researchers evaluated expression of an epidermal growth factor receptor (EGFR)-specific chimeric antigen receptor coded from introduced mRNA in human T cells numerically expanded ex vivo to clinically significant numbers through coculture with activating and propagating cells derived from K562 preloaded with anti-CD3 antibody. [J Immunother] Abstract

Increased Th17 Cells and IL-17A Exist in Patients with B Cell Acute Lymphoblastic Leukemia and Promote Proliferation and Resistance to Daunorubicin through Activation of Akt Signaling
Scientists assessed and observed a significantly increased frequency of Th17 cells and a drastically decreased frequency of Th1 cells in peripheral blood mononuclear cells and bone marrow mononuclear cells from newly diagnosed B-cell acute lymphoblastic leukemia patients compared with healthy donors. [J Transl Med] Full Article

Promoter H3K4 Methylation Dynamically Reinforces Activation-Induced Pathways in Human CD4 T Cells
Researchers have detailed the dynamics of genome-wide promoter H3K4me2 and H3K4me3 over a time course during activation of human naive and memory CD4 T cells. They demonstrated that changes to H3K4 methylation occur relatively late after activation and reinforce activation-induced upregulation of gene expression, affecting multiple pathways important to T-cell activation, differentiation and function. [Genes Immun] Abstract

Aberrant Expression of B7-H4 Correlates with Poor Prognosis and Suppresses Tumor-Infiltration of CD8+ T Lymphocytes in Human Cholangiocarcinoma
The authors investigated the expression of B7-H4 in patients with cholangiocarcinoma and its association with patient prognosis. The correlation between B7-H4 expression and CD4+ and CD8+ tumor-infiltrating lymphocytes was also investigated. [Oncol Rep] Abstract

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TRAF3 as a Powerful and Multitalented Regulator of Lymphocyte Functions
The author summarizes the current state of knowledge regarding the roles of the signaling adapter protein tumor necrosis factor receptor-associated factor 3 in regulating the functions of B and T lymphocytes. [J Leukoc Biol] Abstract

Roles of Regulatory T Cells in Cancer Immunity
The authors address the current understanding of regulatory T cells (Treg)-mediated immune suppressive mechanisms in cancer, the involvement of Tregs in cancer immunotherapy, and strategies for effective and tolerable Treg-targeted therapy. [Int Immunol] Abstract

Visit our reviews page to see a complete list of reviews in the human immunology research field.

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Epizyme to Present Data from the Tazemetostat Non-Hodgkin Lymphoma Program
Epizyme, Inc. announced that data from four abstracts from the company’s clinical development program in support of tazemetostat for use in non-Hodgkin lymphoma will be presented. [Press release from Epizyme, Inc. discussing research to be presented at the American Society of Hematology Meeting on Lymphoma Biology, Colorado Springs] Press Release

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Fluidigm Introduces Single-Cell TCR Sequencing on the C1 System at Immunology 2016™
Fluidigm Corporation announced the introduction of Single-Cell TCR Sequencing, a new immunology application on the C1™ system that enables in-depth profiling of T cells at single-cell resolution. [Fluidigm Corporation] Press Release

Bristol-Myers Squibb and AbbVie Announce European Commission Approval of Empliciti™ (Elotuzumab) for the Treatment of Multiple Myeloma in Adult Patients Who Have Received at Least One Prior Therapy
Bristol-Myers Squibb Company and AbbVie announced that the European Commission has approved Empliciti™ for the treatment of multiple myeloma as combination therapy with Revlimid® and dexamethasone in patients who have received at least one prior therapy. [Bristol-Myers Squibb Company] Press Release

Nimbus Therapeutics Announces Closing of Gilead Sciences’ Acquisition of Nimbus Apollo, Inc., and Its Acetyl-CoA Carboxylase (ACC) Inhibitor Program
Nimbus Therapeutics announced the recent closing of Gilead Sciences, Inc.’s acquisition of Nimbus Apollo, Inc. and its ACC inhibitor program. [Nimbus Therapeutics] Press Release
National Institutes of Health (United States)

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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 21st International AIDS Conference 2016 (AIDS 2016)
July 18-22, 2016
Durban, South Africa

Visit our events page to see a complete list of events in the human immunology community.
NEW Scientific Communications and Publishing Coordinator (STEMCELL Technologies Inc.)

NEW Research Associate – Immunology and Cell Separation (STEMCELL Technologies Inc.)

NEW Technical Sales Representative (STEMCELL Technologies Inc.)

NEW Postdoctoral Research Fellow – Metastatic Microenvironment Immunology (Fred Hutchinson Cancer Research Center)

NEW Postdoctoral Position – Tumor Immunology (Memorial Sloan Kettering Cancer Center)

NEW Postdoctoral Position – Immunology (Saarland University)

NEW Postdoctoral Fellow – Allergy and Immunology (Northwestern University-Feinberg School of Medicine)

NEW Postdoctoral Research Associate – Immunology (Benaroya Research Institute at Virginia Mason)

Research Technologist – T Cell Immunology (STEMCELL Technologies Inc.)

Research Technologist – Cell Separation (STEMCELL Technologies Inc.)

Scientist – Bioengineering (STEMCELL Technologies Inc.)

Senior Scientist – Immunology and Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Fellowship – Immunology (Tongji Medical College)

Postdoctoral Fellow – Immunology (Technische Universität München)

Postdoctoral Fellow – Cancer Biology & Cancer Immunology (Fox Chase Cancer Center)

Faculty Positions – Microbiology and Immunology (National University of Singapore)

Postdoctoral Researchers – Tumor Immunology and Cancer Immunotherapy (University of California, Los Angeles)

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