Crafting a Better T Cell for Immunotherapy
T-cell therapy, a form of immunotherapy that uses a patient’s own immune cells to attack their cancer, has been making waves recently. A group of scientists has devised a new approach that could both speed up and bump up the effectiveness of this process, using a special, small protein tag that can be used to purify and track the T cells once they have been engineered in the laboratory. [Press release from Fred Hutchinson Cancer Research Center discussing online publication in Nature Biotechnology] Press Release|Abstract
The Cytokine Profile of Human NKT Cells and PBMCs Is Dependent on Donor Sex and Stimulus
Scientists analyzed sex-specific differences in peripheral blood natural killer T (NKTs) and peripheral blood mononuclear cells (PBMCs) from men and women and determined the frequencies of NKT cells and their subpopulations and the levels of cytokine production following stimulation with the NKT cell ligands α-Galactosylceramide and Entamoeba histolytica lipopeptidephosphoglycan. [Med Microbiol Immunol] Full Article
DNA Demethylation of the TIM-3 Promoter Is Critical for Its Stable Expression on T Cells
By analyzing the sequences of T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) promoter regions in human and mouse, investigators identified a CpG island within the TIM-3 promoter and demonstrated that the promoter activity was controlled by DNA methylation. [Genes Immun] Abstract
Immunogenic versus Tolerogenic Phagocytosis during Anticancer Therapy: Mechanisms and Clinical Translation
The authors discuss the pivotal role of phagocytosis in regulating responses to anticancer therapy. They give particular attention to the role of phagocytosis following treatment with immunogenic or immune-checkpoint therapies, the clinical prognostic and predictive significance of phagocytic signals for cancer patients and the therapeutic strategies that can be employed for direct targeting of phagocytic determinants. [Cell Death Differ] Abstract
Natural Killer Cell Adoptive Immunotherapy: Coming of Age
The authors discuss protocols for isolation, expansion, and in vitro propagation of large quantities of functional natural killer cells that meet the criteria for clinical applications. [Clin Immunol] Abstract
Visit our reviews page to see a complete list of reviews in the human immunology research field.
INDUSTRY NEWS
Neon Therapeutics Enters Collaborative Research Agreement with the Netherlands Cancer Institute
Neon Therapeutics announced that the company has entered into a collaborative research agreement with the Netherlands Cancer Institute’s Antoni van Leeuwenhoek Hospital and the Amsterdam Biotherapeutics Unit. Under the terms of the agreement, Neon Therapeutics and NKI will combine complementary capabilities to develop personalized T cell therapeutics. [NEON Therapeutics] Press Release
Recruit Top Talent: Reach more than 60,000 potential candidates by posting
your organization’s career opportunities on the Connexon Creative Job Board at no cost.
Have we missed an important article or publication in Human Immunology News? Click here to submit!
