FOXP3 Can Modulate TAL1 Transcriptional Activity through Interaction with LMO2
The authors showed that increased forkhead box P3 (FOXP3) levels negatively correlate with expression of genes regulated by the oncogenic T-cell acute lymphocytic leukemia 1 (TAL1)-complex in human T-cell acute lymphoblastic leukemia (T-ALL) patient samples as well as a T-ALL cell line ectopically expressing FOXP3. [Oncogene] Abstract
Accumulation Mechanisms of CD4+CD25+FOXP3+ Regulatory T Cells in EBV-Associated Gastric Carcinoma
Because regulatory T cells (Tregs) are regarded as a critical hurdle in anti-tumour immunity, researchers assessed the distribution of Tregs in 45 cases of Epstein-Barr virus (EBV)-associated gastric carcinomas and 45 cases of EBV-negative gastric carcinoma with matched clinicopathological parameters by immunohistochemistry. [Sci Rep] Full Article
Human Regulatory T Cells Control TCR Signaling and Susceptibility to Suppression in CD4+ T Cells
Scientists demonstrated that T cell receptors and costimulation are required to activate the regulatory T cell suppressive function. Regulatory T cells suppressed the T cell receptor signaling in effector T cells in a time-dependent manner that corresponded with inhibition of cytokine production and proliferation. [J Leukoc Biol] Abstract
Regulatory T Cell Memory
The authors consider the parallels between memory effector T cells and memory regulatory T cells, along with the functional implications of regulatory memory in autoimmunity, antimicrobial host defence and maternal–fetal tolerance. In addition, they discuss emerging evidence for regulatory T cell memory in humans and key unanswered questions in this rapidly evolving field. [Nat Rev Immunol] Abstract
Tissue-Resident Memory T Cells: Local Specialists in Immune Defence
The author discuss the major advances and the emerging concepts in this field, summarize what is known about the differentiation and the protective functions of tissue-resident memory T cells in different tissues in the body and highlight key unanswered questions. [Nat Rev Immunol] Abstract
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