Scientists Find Way to Make Leukemia Cells Kill Each Other
Scientists have found a way to change leukemia cells into leukemia-killing immune cells. The surprise finding could lead to a powerful new therapy for leukemia and possibly other cancers. [Press release from The Scripps Research Institute discussing online prepublication in Proceedings of the National Academy of Sciences] Press Release|Abstract
The HLA-G Cycle Provides for Both NK Tolerance and Immunity at the Maternal–Fetal Interface
Filamentous projections from extravillous trophoblasts enriched in HLA-G were shown to contact decidual natural killer cells (dNK), and may represent the initial stage of synapse formation. Activation of dNK resulted in the disappearance of internalized HLA-G in parallel with restoration of cytotoxicity. [Proc Natl Acad Sci USA] Abstract
Antigenically Modified Human Pluripotent Stem Cells Generate Antigen-Presenting Dendritic Cells
Antigenically modified human pluripotent stem cells (hPSCs) were able to differentiate into tumor antigen-presenting dendritic cells (DCs). Without conventional antigen-loading, DCs derived from the minigene-modified hPSCs were ready to prime a tumor antigen-specific T cell response and further expand these specific T cells in restimulation processes. [Sci Rep] Full Article
Mobilization without Immune Depletion Fails to Restore Immunological Tolerance or Preserve Beta Cell Function in Recent Onset Type 1 Diabetes
The authors tested the potential of granulocyte colony stimulating factor (G-CSF) to impact type 1 diabetes progression in patients with recent-onset disease and assessed safety, efficacy, and mechanistic effects on the immune system. They hypothesized that pegylated G-CSF would promote regulatory T cell mobilization to a degree capable of restoring immunological tolerance and thus, preventing further decline in C-peptide production. [Clin Exp Immunol] Abstract
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