Turning T Cell Immunology on Its Head
Until now, the assumption has been that the receptors on the T cells (TCRs) must bind to the major histocompatibility complex (MHC) in a specific orientation in order to trigger a signal to the immune system. Researchers demonstrated for the first time that TCRs can bind with a completely reversed orientation — compared to all previously studied receptors. [Press release from the Centre for Advanced Molecular Imaging discussing online prepublication in Nature Immunology] Press Release|Abstract
Sialylation of IgG Fc Domain Impairs Complement-Dependent Cytotoxicity
The authors report that IgG fragment crystallizable (Fc) sialylation of human monoclonal IgG1 molecules impairs their efficacy to induce complement-mediated cytotoxicity. Fc sialylation of a CD20-targeting antibody had no impact on antibody-dependent cellular cytotoxicity and did not change the affinity of the antibody for activating Fcγ receptors. [J Clin Invest] Full Article|Press Release
Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human
Scientists report the presence of a cell population in the bone marrow of the cytokine-treated humanized mice that express both natural killer cell marker CD56 and myeloid markers such as CD36 and CD33. The CD56+CD33+CD36+ cells are also found in human cord blood, fetal and adult bone marrow. [Sci Rep] Full Article
Lymphocyte Phosphatase-Associated Phosphoprotein Proteoforms Analyzed Using Monoclonal Antibodies
Researchers determined the pattern of lymphocyte phosphatase-associated phosphoprotein (LPAP) expression in various cell types and characterized its proteoforms using new monoclonal antibodies generated against the intracellular portion of the protein. They showed that LPAP is a pan-lymphocyte marker, and its expression in cells correlates with the expression of CD45. [Clin Transl Immunol] Full Article
γδ T Cells in Cancer
Investigators integrate the current knowledge from both human and mouse studies to highlight the potential of γδ T cell modulation to improve cancer immunotherapy. [Nat Rev Immunol] Abstract
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SCIENCE NEWS
OncBioMune Presents Data on Novel Cancer Vaccine ProscaVax
OncBioMune Pharmaceuticals, Inc. announced that Dr. Jonathan Head presented interim data on the company’s Phase I clinical trial of the novel vaccine ProscaVax for prostate cancer. [Press release from OncBioMune Pharmaceuticals, Inc. (Marketwired L.P.) discussing research presented at CRI-CIMT-EATI-AACR – The Inaugural International Cancer Immunotherapy Conference, New York] Press Release|Presentation
Advaxis’s Cancer Immunotherapies to Be Featured in Three Poster Presentations
Advaxis, Inc. announced that three abstracts featuring Advaxis’s Lm Technology™ cancer immunotherapies have been selected for poster presentation. [Press release from Advaxis, Inc. discussing research to be presented at the Society for Immunotherapy of Cancer’s (SITC) 30th Anniversary Annual Meeting, National Harbor] Press Release
Cancer Research UK Launches £100 Million Grand Challenges to Tackle the Most Important Questions in Cancer
Cancer Research UK has launched Grand Challenges – the biggest and most ambitious cancer grants in the world – which aim to overcome the greatest barriers standing in the way of beating cancer. The £100 million investment will revolutionize how we diagnose, prevent and treat cancer by uniting teams of the best scientists around the world to come up with answers to crucial questions about how to save more lives from cancer. [Cancer Research UK] Press Release
NYBC Laboratories Receive almost $4 Million in NIH Grants
NYBC’s Laboratory of Complement Biology at its Lindsley F. Kimball Research Institute has received a significant federal grant to identify the immune cells that block medications commonly used to treat patients with immune thrombocytopenia – an autoimmune bleeding disease in which patients attack and destroy their own platelets, the blood component primarily responsible for controlling bleeding. [New York Blood Center (NYBC)] Press Release
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