| | | TOP STORY |
Therapeutic Bispecific T-Cell Engager Antibody Targeting the Intracellular Oncoprotein WT1
The authors describe a bispecific T-cell engager (BiTE) antibody derived from a T-cell receptor-mimic monoclonal antibody ESK1, which binds a peptide derived from the intracellular oncoprotein WT1 presented on human leukocyte antigen-A*02:01. Despite the very low density of the complexes at the cell surface, ESK1-BiTE selectively activated and induced proliferation of cytolytic human T cells that killed cells from multiple leukemias and solid tumors in vitro and in mice. [Nat Biotechnol] Abstract |
|
| | | PUBLICATIONS (Ranked by impact factor of the journal) |
The Ro60 Autoantigen Binds Endogenous Retroelements and Regulates Inflammatory Gene Expression
Investigators cataloged the Ro60-associated RNAs in human cell lines and found that among other RNAs, Ro60 bound an RNA motif derived from endogenous Alu retroelements. Alu transcripts were induced by type I interferon and stimulated pro-inflammatory cytokine secretion by human peripheral blood cells. [Science] Abstract
TCR-Induced Sumoylation of the Kinase PKC-θ Controls T Cell Synapse Organization and T Cell Activation
Scientists found that the kinase PKC-θ was sumoylated upon costimulation with antigen or via the T cell antigen receptor (TCR) plus the coreceptor CD28, with Lys325 and Lys506 being the main sumoylation sites. Analysis of primary mouse and human T cells revealed that sumoylation of PKC-θ was essential for T cell activation. [Nat Immunol] Abstract
Chimeric Antigen Receptor-Modified T Cells Derived from Defined CD8+ and CD4+ Subsets Confer Superior Antitumor Reactivity In Vivo
Investigators analyzed CD19 CAR-expressing effector T-cells derived from different subsets (CD4+/CD8+ naïve, central memory, effector memory). T-cells derived from each of the subsets were efficiently transduced and expanded, but showed clear differences in effector function and proliferation in vitro and in vivo. [Leukemia] Abstract
Multiple Sclerosis Associated Genetic Variants of CD226 Impair Regulatory T Cell Function
Researchers investigated phenotypical and functional consequences of a genetic variant in the CD226 gene that, among other autoimmune diseases, predisposes to multiple sclerosis. Phenotypically, effector and regulatory CD4+ memory T cells of healthy individuals carrying the predisposing CD226 genetic variant showed, in comparison to carriers of the protective variant, reduced surface expression of CD226 and an impaired induction of CD226 after stimulation. [Brain] Abstract
Inhibition of Super-Enhancer Activity in Autoinflammatory Site-Derived T Cells Reduces Disease-Associated Gene Expression
With H3K27ac chromatin immunoprecipitation, scientists identified a disease-specific, inflammation-associated, typical enhancer and super-enhancer signature in juvenile idiopathic arthritis patient synovial-fluid-derived CD4+ memory/effector T cells. [Cell Rep] Full Article
|
Graphical Abstract
Immunological Adaptations to Pregnancy in Women with Type 1 Diabetes
The systemic immune response was assessed by using flow cytometry to evaluate the number and activational status of subpopulations of lymphocytes, natural killer cells and monocytes in peripheral blood of non-pregnant and pregnant women with and without type 1 diabetes. [Sci Rep] Full Article
NK Cells Preferentially Target Tumor Cells with a Cancer Stem Cell Phenotype
Researchers demonstrated that activated NK cells are capable of preferentially killing cancer stem cells (CSCs) identified by multiple CSC markers from a wide variety of human cancer cell lines in vitro and dissociated primary cancer specimens ex vivo. [J Immunol] Abstract
Signal Strength and Metabolic Requirements Control Cytokine-Induced Th17 Differentiation of Uncommitted Human T Cells
Human Th17 cells can be efficiently generated with appropriate cytokines from precommitted precursors, but the requirements of uncommitted T cells are still ill defined. In standard human Th17 cultures, IL-17 production was restricted to CCR6+CD45RA+ T cells, which expressed CD95 and produced IL-17 ex vivo, identifying them as Th17 memory stem cells. [J Immunol] Abstract
Bispecific Antibody Releasing-Mesenchymal Stromal Cell Machinery for Retargeting T Cells towards Acute Myeloid Leukemia Blasts
Researchers examined the use of mesenchymal stromal cells as autonomous cellular machines for the constant production of a recently described, fully humanized anti-CD33-anti-CD3 bispecific antibody, which is capable of redirecting human T cells against CD33-expressing leukemic cells. [Blood Cancer J] Full Article
Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News!
|
| | | REVIEWS |
The Interplay between Inflammation and Metabolism in Rheumatoid Arthritis
The extent of the metabolic changes and the types of metabolites seen may be good markers of cytokine-mediated inflammatory processes in rheumatoid arthritis (RA). The authors review the metabolic changes occurring in the pathogenesis of RA as well as the implication of the metabolic features in the treatment response. [Cell Death Dis] Full Article
Visit our reviews page to see a complete list of reviews in the Human Immunology research field.
|
|
