Volume 3.28 | Jul 21

Human Immunology News 3.28 July 21, 2015
Human Immunology News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Investigational T-Cell Receptor Therapy Achieves Encouraging Clinical Responses in Multiple Myeloma Patients
Researchers modified T cells to attack cancer cells expressing NY-ESO-1, an antigen found in nearly 60 percent of multiple myelomas and previously shown to be associated with tumor growth and poor prognosis. [Press release from the University of Pennsylvania discussing online prepublication in Nature Medicine]
Press Release
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PUBLICATIONS (Ranked by impact factor of the journal)
Genomic Landscape of Cutaneous T Cell Lymphoma
Scientists performed exome and whole-genome DNA sequencing and RNA sequencing on purified cutaneous T cell lymphoma (CTCL) and matched normal cells. The results implicate mutations in 17 genes in CTCL pathogenesis, including genes involved in T cell activation and apoptosis, NF-κB signaling, chromatin remodeling and DNA damage response. [Nat Genet] Abstract | Press Release

Interleukin-12 and -23 Control Plasticity of CD127+ Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria
Researchers found that differentiation of ILC3 to CD127+ ILC1 is reversible in vitro and in vivo. CD127+ ILC1 differentiated to ILC3 in the presence of interleukin-2 (IL-2), IL-23, and IL-1β dependent on the transcription factor RORγt, and this process was enhanced in the presence of retinoic acid. [Immunity]
Abstract
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Mesenchymal Stromal Cells Prevent Allostimulation In Vivo and Control Checkpoints of Th1 Priming: Migration of Human DC to Lymph Nodes and NK Cell Activation
Scientists investigated the impact of mesenchymal stromal cells on the functionality of human myeloid dendritic cells (DCs) and the consequences for natural killer (NK) cell and Th1 priming in vitro and in vivo. [Stem Cells] Abstract

Evidence for the Involvement of Gamma Delta T Cells in the Immune Response in Rasmussen Encephalitis
Peripheral blood mononuclear cells and brain-infiltrating lymphocytes were isolated from 20 Rasmussen encephalitis surgery specimens by standard methods, and CD3+ T cell populations were analyzed by flow cytometry. [J Neuroinflamm] Full Article

Opportunistic Pathogen Candida albicans Elicits a Temporal Response in Primary Human Mast Cells
Scientists showed that human mast cells mounted specific responses towards C. albicans. Collectively, mast cell responses included the launch of initial, intermediate and late phase components determined by the secretion of granular proteins and cytokines. [Sci Rep] Full Article

Characterization of Species-Specific Genes Regulated by E2-2 in Human Plasmacytoid Dendritic Cells
Basic helix-loop-helix protein E2-2 is defined as an essential transcription factor for mouse plasmacytoid dendritic cells (pDCs) development, cell fate maintenance and gene program. The authors investigated the function of E2-2 in human pDCs and screened human-specific genes regulated by E2-2. [Sci Rep] Full Article

Analysis of CD8+ Treg Cells in Patients with Ovarian Cancer: A Possible Mechanism for Immune Impairment
Scientists investigated CD8+ regulatory T (Treg) cells in ovarian cancer patients and their in vitro induction. Compared with the CD8+ T cells cultured alone, the CD8+ Treg cells induced in vitro by coculture with SK-OV-3/A2780 showed increased CTLA-4 and Foxp3 expression and decreased CD28 expression. [Cell Mol Immunol] Full Article

Caspase-4 Mediates Non-Canonical Activation of the NLRP3 Inflammasome in Human Myeloid Cells
Researchers showed that the human monocytic cell line THP1 activates the inflammasome in response to cytosolic LPS in a TLR4-independent fashion. This response is mediated by caspase-4 and accompanied by caspase-1 activation, pyroptosis and interleukin 1β maturation. [Eur J Immunol] Abstract

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REVIEWS
Advances on Non-CD4+ Foxp3+ T Regulatory Cells: CD8+, Type 1, and Double Negative T Regulatory Cells in Organ Transplantation
The overwhelming body of research on T regulatory cells (Treg) has focused on CD4+ CD25+ Foxp3+ T cells. However, recent years have witnessed a resurgence in interest in CD4CD8+, CD4CD8, and CD4+Foxp3 type 1 Treg and their role in controlling autoimmune diseases and in promoting the survival of organ allografts and xenografts. [Transplantation] Abstract

Origin and Functions of Pro-Inflammatory Cytokine Producing Foxp3+ Regulatory T Cells
The authors review the mechanisms of development and the possible functions of pro-inflammatory cytokine producing Foxp3+ Tregs. [Cytokine] Abstract

Visit our reviews page to see a complete list of reviews in the human immunology research field.

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INDUSTRY NEWS
Roche’s Investigational Immunotherapy Atezolizumab Shrank Tumors in People with a Specific Type of Bladder Cancer
Roche announced that in the IMvigor 210 study, the investigational cancer immunotherapy atezolizumab shrank tumors in people with locally advanced or metastatic urothelial bladder cancer who had progressed on initial treatment. [F. Hoffmann-La Roche Ltd] Press Release

Oxford Immunotec Inks Licensing Agreement with IDIBELL for B Cell Measurement Technology
Oxford Immunotec Global PLC announced that it has exclusively licensed technology that measures antibody-secreting B cells from Bellvitge Biomedical Research Institute (IDIBELL). [Oxford Immunotec Global PLC] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Tumor Immunology and Immunotherapy 2015
September 21-25, 2015
Suzhou, China

NEW 4th International Conference on Immunotherapy in Pediatric Oncology (CIPO2015)
September 25-26, 2015
Seattle, Washington

Visit our events page to see a complete list of events in the human immunology community.
 
JOB OPPORTUNITIES
NEW Research Associate – Cell Biology (Editas Medicine)

NEW Senior Research Associate (Editas Medicine)

NEW Postdoctoral Researcher – Immunology (New York University School of Medicine)

NEW Postdoctoral Fellow – Immunology (Cellectis Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Scientific Marketing Specialist – Immunology (STEMCELL Technologies Inc.)

Postdoctoral Fellowship – Immunology (Huazhong University of Science and Technology)

Postdoctoral Position – Translational Immunology (University of Utah School of Medicine)

Postdoctoral Fellow – Antibody Engineering/Immuno-Oncology (California Institute for Biomedical Research)

Process Facilitator (Opexa Therapeutics)


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