Volume 3.11 | Mar 24

Human Immunology News 3.11 March 24, 2015
Human Immunology News
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Gene Discovery Provides Clues to How TB May Evade the Immune System
The largest genetic study of tuberculosis (TB) susceptibility to date has led to a potentially important new insight into how the pathogen manages to evade the immune system. [Press release from the University of Cambridge discussing online prepublication in Nature Genetics] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Epigenetic Modification and Antibody-Dependent Expansion of Memory-Like NK Cells in Human Cytomegalovirus-Infected Individuals
Investigators showed that human cytomegalovirus-infected individuals have several distinct subsets of memory-like NK cells that are often deficient for multiple transcription factors and signaling proteins, including tyrosine kinase SYK, for which the reduced expression was stable over time and correlated with epigenetic modification of the gene promoter. [Immunity] Abstract | Graphical Abstract

Cytomegalovirus Infection Drives Adaptive Epigenetic Diversification of NK Cells with Altered Signaling and Effector Function
The authors describe the emergence of diverse subsets of human natural killer (NK) cells selectively lacking expression of signaling proteins after human cytomegalovirus infection. [Immunity] Abstract

Human Skin Is Protected by Four Functionally and Phenotypically Discrete Populations of Resident and Recirculating Memory T Cells
Scientists discriminated resident from recirculating T cells in human-engrafted mice and lymphoma patients using alemtuzumab, a medication that depletes recirculating T cells from skin, and then analyzed these T cell populations in healthy human skin. [Sci Transl Med] Abstract

Regulatory vs. Inflammatory Cytokine T-Cell Responses to Mutated Insulin Peptides in Healthy and Type 1 Diabetic Subjects
Investigators report CD4 T-cell responses to a mutated insulin B-chain peptide in new-onset and established type 1 diabetes as well as control subjects dependent on HLA-DQ genotype. [Proc Natl Acad Sci USA]
Abstract | Full Article

Autoantigen BiP-Derived HLA-DR4 Epitopes Differentially Recognized by Effector and Regulatory T Cells in Rheumatoid Arthritis
The proliferation and cytokine secretion of peripheral blood mononuclear cells from HLA-DR4-positive rheumatoid arthritis patients in response to immunoglobulin-binding protein (BiP)-derived peptides were examined by 3H-thymidine uptake and ELISA. [Arthritis Rheumatol] Abstract

Presence of Circulating Her-2-Reactive CD8+ T-Cells Is Associated with Lower Frequencies of Myeloid-Derived Suppressor Cells and Regulatory T Cells, and Better Survival in Elderly Breast Cancer Patients
Investigators assessed the frequency of peripheral regulatory T-cells and myeloid-derived suppressor cells in relation to in vitro T-cell responses to Her-2 antigen in 40 untreated breast cancer patients 65 to 87 years of age at diagnosis. [Breast Cancer Res] Abstract | Full Article

The Immunosuppressive Enzyme IL4I1 Promotes FoxP3+ Regulatory T Lymphocyte Differentiation
Researchers explored the effect of IL4I1 on naïve CD4+ T-cell differentiation. They showed that IL4I1 stimulates the generation of Foxp3+ regulatory T cells in vitro from human and mouse T cells. [Eur J Immunol] Abstract

Naive CD8+ T-Cell Precursors Display Structured TCR Repertoires and Composite Antigen-Driven Selection Dynamics
Researchers used high-definition cell isolation from umbilical cord blood samples to establish the baseline frequency, phenotype and T-cell antigen receptor (TCR) repertoire of CD8+ T-cell precursor populations specific for a range of viral and self-derived antigens. [Immunol Cell Biol] Full Article

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Hematological Malignancies: At the Forefront of Immunotherapeutic Innovation
The immune-cell origin of many of the blood malignancies provides a unique opportunity both to understand the mechanisms of cancer immune responsiveness and immune evasion, and to exploit these mechanisms for therapeutic purposes. [Nat Rev Cancer] Abstract

Visit our reviews page to see a complete list of reviews in the human immunology research field.
Kineta’s ShK-186 Shows Encouraging Early Results as Potential Therapy for Autoimmune Eye Diseases
Kineta, Inc. presented encouraging pre-clinical animal results using ShK-186 in a novel ocular formulation as a topical therapy for autoimmune eye disease. [Press release from Kineta, Inc. discussing research presented at the 7th Ocular Diseases Drug Discovery Conference, San Diego] Press Release | Poster

Argos Therapeutics Director of Immunology to Present at HIV Vaccines Meeting
Dr. Mark DeBenedette, the company’s director of immunology, reviewed immunologic outcomes from a double blind placebo controlled Phase IIb clinical trial of AGS-004, the company’s investigational immunotherapy for the treatment of HIV. [Press release from Argos Therapeutics Inc. discussing research presented at the Keystone Symposium HIV Vaccines Meeting, Banff] Press Release

Lycera to Present at the 2015 American Association for Cancer Research Annual Meeting
Lycera Corp. announced that the company will present preclinical research from its novel cancer immunotherapy program. [Press release from Lycera Corp. discussing research to be presented at the 2015 American Association for Cancer Research (AACR) Annual Meeting, Philadelphia] Press Release | Abstract

Advaxis’s Lm-LLO Immunotherapy Platform to be Featured in Three Poster Presentations
Advaxis, Inc. announced that three abstracts revealing new data for Advaxis’s proprietary Lm-LLO cancer immunotherapy platform have been selected for poster presentations. [Press release from Advaxis, Inc. discussing research to be presented at the 2015 American Association for Cancer Research (AACR) Annual Meeting, Philadelphia] Press Release

Transgene Announces New Pre-Clinical Data with TG4010 in Combination with Immune Checkpoint Inhibitors and TG3003 (Humanized mAb Anti-CD115)
Transgene announced that new pre-clinical data with two of its immunotherapy programs will be presented. [Press release from Transgene discussing research to be presented at the 2015 American Association for Cancer Research (AACR) Annual Meeting, Philadelphia] Press Release

RedHill Biopharma to Present at the 3rd Annual Autoimmune & Inflammation Leaders’ Forum
Ira Kalfus, MD, RedHill’s Medical Director, will present a case study utilizing therapy targeting Mycobacterium avium paratuberculosis and the study rationale for RedHill’s ongoing RHB-104 Phase III Crohn’s disease development program. [Press release from RedHill Biopharma Ltd. discussing research to be presented at the 3rd Annual Autoimmune & Inflammation Leaders’ Forum, Boston] Press Release

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Celldex Therapeutics Announces Clinical Trial Collaboration with Roche to Evaluate the Combination of Varlilumab and MPDL3280A
Celldex Therapeutics, Inc. announced that it has entered into a clinical trial collaboration with Roche to evaluate the safety, tolerability and preliminary efficacy of varlilumab, Celldex’s CD27 targeting investigational antibody, and MPDL3280A (anti-PDL1), Roche’s investigational cancer immunotherapy in a Phase I/II study in renal cell carcinoma. [Celldex Therapeutics, Inc.] Press Release

A Vaccine against Placental Malaria Made with ExpreS2ion Biotechnologies’ Protein Expression Technology, ExpreS2, Is Ready to Start Human Tests in Germany and Benin
ExpreS2ion Biotechnologies announced the release by its partners at University of Copenhagen, of a vaccine candidate against the form of malaria that strikes pregnant women, for testing in humans. [ExpreS2ion Biotechnologies] Press Release

Advaxis Announces First Patient Treated in Phase I/II Dose-Escalation Study of ADXS-HPV for Recurrent Cervical Cancer
Advaxis, Inc. announced that the first patient was dosed in a Phase I/II clinical trial evaluating higher doses and repeat cycles of ADXS-HPV, an investigational Lm-LLO immunotherapy, for the treatment of patients with recurrent cervical cancer. [Advaxis, Inc.] Press Release

Cell Medica Granted Orphan Drug Designation for Novel Cellular Therapy; Treats First Lymphoma Patient in Phase II Trial
Cell Medica announced that the U.S. Food and Drug Administration has granted Orphan Drug Designation to the company’s cancer immunotherapy treatment, referred to as CMD-003, under development for Epstein-Barr Virus positive non-Hodgkin lymphomas. [Cell Medica] Press Release

Immunovaccine Initiates Phase II Clinical Trial of DPX-Survivac Immunotherapy in Recurrent Lymphoma
Immunovaccine Inc. announced that it has treated the first patient with diffuse large B cell lymphoma in a Phase II clinical study of its lead cancer immunotherapy DPX-Survivac. [Immunovaccine Inc.] Press Release
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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW EMBO Workshop – Cellular and Molecular Mechanism of Tumor-Microenvironment Crosstalk
July 9-12, 2015
Tomsk, Russia

NEW Gordon Research Conference – Hormone-Dependent Cancers
August 16-21, 2015
Newry, United States

Visit our events page to see a complete list of events in the human immunology community.
NEW Research Officer – Immunology (Glenmark Pharmaceuticals S.A.)

Postdoctoral Fellow – Diffuse Large B-cell Lymphoma (University of Leeds)

Manufacturing Manager – Cell Therapy (Opexa Therapeutics)

Senior Research Officer – Immunology (Glenmark Pharmaceuticals S.A.)

Postdoctoral Fellowship – Human Immunology (University of Pennsylvania)

Postdoctoral Position – Immunology (The Broad Institute of MIT and Harvard)

Senior Process Development Engineer (Sangamo BioSciences, Inc.)

Director – Vector Production (Sangamo BioSciences, Inc.)

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