Volume 3.03 | Jan 27

Human Immunology News 3.03 January 27, 2015
Human Immunology News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY
Cancer-Causing Virus Blocks Human Immune Response
Scientists identified microRNAs made by several herpes viruses that block a component of a human’s innate immune system called the interferon response. They found that several herpes viruses have independently evolved similar mechanisms to block the host’s interferon response. [Press release from The University of Texas at Austin discussing online publication in Proceedings of the National Academy of Sciences]
Press Release | Abstract
Learn more about the new smartphone app for human blood cell frequencies
 
PUBLICATIONS (Ranked by impact factor of the journal)
Evaluation of the Immunomodulatory Effect of Melatonin on the T-Cell Response in Peripheral Blood from Systemic Lupus Erythematosus Patients
Investigators analyzed the role of in vitro administered melatonin in the immune response of peripheral leukocytes from treated systemic lupus erythematosus patients and age- and sex-matched healthy controls. [J Pineal Res] Abstract

Phenotypic Diversity and Plasticity in Circulating Neutrophil Subpopulations in Cancer
Scientists identified a heterogeneous subset of low-density neutrophils (LDNs) that appear transiently in self-resolving inflammation but accumulate continuously with cancer progression. LDNs consist of both immature myeloid-derived suppressor cells and mature cells that are derived from high-density neutrophils in a TGF-β-dependent mechanism. [Cell Rep] Full Article | Graphical Abstract | Press Release

MicroRNA-125b Modulates Inflammatory Chemokine CCL4 Expression in Immune Cells and Its Reduction Causes CCL4 Increase with Age
Researchers report the role of microRNA-125b in regulating inflammatory CC chemokine 4 (CCL4) expression in human immune cells and its altered expression with aging. They observed that monocytes and naïve CD8 T cells expressed higher levels of CCL4 and exhibited an age-related increase in CCL4. [Aging Cell] Full Article

DNA Methyltransferase Inhibition Accelerates the Immunomodulation and Migration of Human Mesenchymal Stem Cells
Scientists treated human mesenchymal stem cells with 5-azacytidine, a DNA methyltransferase inhibitor, and confirmed that the inhibitory effects on mononuclear cell proliferation and cell migration toward activated T cells were increased. [Sci Rep] Full Article

Serum Macrophage-Derived Chemokine/CCL22 Levels Are Associated with Glioma Risk, CD4 T Cell Lymphopenia and Survival Time
Investigators measured peripheral CCL22, a dendritic cell/macrophage derived T cell trafficking chemokine, in sera from 1,208 glioma cases and 976 controls to assess whether it might provide a biomarker of glioma risk, survival, and immune dysfunction. [Int J Cancer] Abstract

Clinical Outcomes of a Novel Therapeutic Vaccine with Tax Peptide-Pulsed Dendritic Cells for Adult T Cell Leukemia/Lymphoma in a Pilot Study
Researchers developed a novel therapeutic vaccine designed to augment an human T cell leukemia virus type-I Tax-specific cytotoxic T lymphocyte response that has been implicated in anti-adult T cell leukemia/lymphoma effects, and conducted a pilot study to investigate its safety and efficacy. [Br J Haematol] Abstract

Anti-Inflammatory T-Cell Shift in Neuropathic Pain
Researchers investigated systemic T-cell subset responses and T-cell related cytokine profiles in patients with chronic neuropathic pain. They found a T helper 17 (TH17)/regulatory T-cell (Treg) imbalance with significantly increased anti-inflammatory Tregs and decreased pro-inflammatory TH17 cells in patients with neuropathic pain as compared to healthy controls. [J Neuroinflammation] Full Article

Inhibition of T-Cell Activation by Retinal Pigment Epithelial Cells Derived from Induced Pluripotent Stem Cells
Scientists determined whether human retinal pigment epithelial cells (RPE) from induced pluripotent stem (iPS) cells can inhibit T-cell activation in vitro. The cultured iPS-RPE cells inhibited cell proliferation and the production of IFN-γ by activated CD4+ T cells. [Invest Ophthalmol Vis Sci] Abstract

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REVIEWS
Role of Innate and Adaptive Immune Mechanisms in Cardiac Injury and Repair
The authors summarize the role of the immune system in cardiovascular disease — focusing on the idea that the immune system evolved to promote tissue homeostasis following injury and/or infection, and that the inherent cost of this evolutionary development is unwanted inflammatory damage. [Nat Rev Immunol] Abstract

Epstein-Barr Virus-Positive T/NK-Cell Lymphoproliferative Disorders
Investigators describe the current knowledge of the genetics, oncogenesis, biology, diagnosis and treatment of Epstein-Barr virus-associated T/natural killer (NK) cell lymphoproliferative diseases. [Exp Mol Med] Full Article

Designing Chimeric Antigen Receptors to Effectively and Safely Target Tumors
The authors discuss recent concepts in the development of effective and safe synthetic chimeric antigen receptors for adoptive T cell therapy. [Curr Opin Immunol] Abstract

Visit our reviews page to see a complete list of reviews in the human immunology research field.
 
SCIENCE NEWS
Aduro Biotech Reports Long-Term Survival and Immune Biomarker Data from Phase II Clinical Trial of Its Immuno-Oncology Regimen in Patients with Pancreatic Cancer
Aduro Biotech, Inc. announced that seven pancreatic cancer patients treated with its combination immuno-oncology regimen in a 93-patient Phase IIa clinical trial continue in survival follow-up. [Press release from Aduro Biotech, Inc. discussing research presented at the American Society of Clinical Oncology (ASCO) 2015 Gastrointestinal Cancers Symposium, San Francisco] Press Release

Heat Biologics, Inc. Presents Positive Immunological Data on HS-410 in Non-Muscle Invasive Bladder Cancer
Heat Biologics, Inc. announced positive data demonstrating substantially increased tumor infiltrating lymphocytes following treatment in its Phase I clinical trial of HS-410 in non-muscle invasive bladder cancer. [Press release from Heat Biologics, Inc. discussing research presented at the 7th Annual Phacilitate Immunotherapy Forum 2015, Washington, DC] Press Release

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INDUSTRY NEWS
SITC, Merck to Support Innovative Cancer Immunotherapy Research
The Society for Immunotherapy of Cancer (SITC)-Merck Cancer Immunotherapy Clinical Fellowship Award, available to individuals holding MD or joint MD/PhD degrees, is an opportunity for young investigators to catalyze their research and advance the science and application of cancer immunotherapy. [Society for Immunotherapy of Cancer] Press Release

NRC, Lilly Creek and AMRIC Join Forces on Vaccine to Prevent Gastritis, Ulcers, and Gastric Cancer
Researchers at the National Research Council of Canada (NRC), the Advanced Medical Research Institute of Canada (AMRIC) and Lilly Creek Vaccines are developing a new vaccine to combat and eradicate Helicobacter pylori infection in Canada. [National Research Council of Canada] Press Release

Kite Pharma Announces Expanded Agreement with Tel Aviv Sourasky Medical Center and Pioneering Researcher Professor Zelig Eshhar to Develop Novel Chimeric Antigen Receptor (CAR) Approaches for Cancer Immunotherapy
Kite Pharma, Inc. announced that the company has expanded its agreement with Tel Aviv Sourasky Medical Center to research and develop novel approaches to CAR T cell therapy. [Kite Pharma, Inc.] Press Release

Patent for the Production of Immunicum’s Therapeutic Cancer Vaccines to Be Granted in Europe
Immunicum AB announced that the European Patent Office has announced its intention to grant a patent pertaining to the production method of the company’s therapeutic cancer vaccines. [Immunicum AB] Press Release

NCCS Conducts World’s First-in-Human Clinical Trial of a Novel Vaccine Targeting Top Cancers
The National Cancer Centre Singapore (NCCS) has launched a clinical trial of a new cancer vaccine administered to human patients for the first time in the world. [National Cancer Centre Singapore] Press Release
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Keystone Symposium – Mechanisms of Pro-Inflammatory Diseases
April 19-24, 2015
Olympic Valley, United States

NEW 4th European Congress of Immunology (ECI) 2015
September 6-9, 2015
Vienna, Austria

NEW World Conference on Regenerative Medicine
October 21-23, 2015
Leipzig, Germany

Visit our events page to see a complete list of events in the human immunology community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Fellow – Innate-Adaptive Interface in Autoimmunity (Singapore Immunology Network A*STAR)

Director (California Institute for Regenerative Medicine)

Postdoctoral Position – Inflammatory Bowel Disease (The Technical University of Denmark)

Postdoctoral Position – Cancer-Related Inflammation (Institute of Human Genetics)

Tenure-Track Assistant Professor – Pathology (Stanford University School of Medicine)

Senior Research Scientist – Immunohistochemistry (iTeos Therapeutics)

Research Scientist – Cancer Immunotherapy (iTeos Therapeutics)

Senior Medical Advisor – Inflammation & Immunology (Celgene Corporation)

Scientist – Recombinant Molecules and Antibodies (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)


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