Volume 3.00 | Jan 6

Human Immunology News 3.00 January 6, 2015
Human Immunology News
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mTOR Inhibition Improves Immune Function in the Elderly
To begin to assess the effects of mammalian target of rapamycin (mTOR) inhibition on human aging-related conditions, scientists evaluated whether the mTOR inhibitor RAD001 ameliorated immunosenescence in elderly volunteers, as assessed by their response to influenza vaccination. [Sci Transl Med] Abstract | Editorial
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PUBLICATIONS (Ranked by impact factor of the journal)
Syk Is Indispensable for CpG-Induced Activation and Differentiation of Human B Cells
Investigators describe a so far unidentified, spleen tyrosine kinase (Syk)-dependent pathway, which is indispensable for CpG-induced human B cell activation. They show that triggering of B cells by CpG results in Syk and src kinase phosphorylation, proliferation, as well as cytokine and antibody production independent of the BCR. [Cell Mol Life Sci] Abstract

CD26-Mediated Induction of EGR2 and IL-10 as Potential Regulatory Mechanism for CD26 Costimulatory Pathway
Scientists examined the expression of inhibitory molecules induced via CD26-mediated costimulation. They show that coengagement of CD3 and CD26 induces preferential production of IL-10 in human CD4+ T cells, mediated through NFAT and Raf-MEK-ERK pathways. [J Immunol] Abstract

Combination Therapy with Anti-CTLA-4 and Anti-PD-1 Leads to Distinct Immunologic Changes In Vivo
Investigators show that blockade of CTLA-4, PD-1, or combination of the two leads to distinct genomic and functional signatures in vivo in purified human T cells and monocytes. [J Immunol] Abstract

Induced Expression of FcγRIIIa (CD16a) on CD4+ T Cells Triggers Generation of IFN-γhigh Subset
The authors show that a subset of activated CD4+ T-cells in humans express FcγRIIIa. The ligation of FcγRIIIa by immune complexes in human CD4+ T-cells produced co-stimulatory signal like CD28 that triggered IFN-γ production. [J Biol Chem] Abstract | Full Article

Monocyte-Derived Dendritic Cells Can Induce Autoreactive CD4+ T Cells Showing Myeloid Lineage-Directed Reactivity in Healthy Individuals
Researchers show that a minority of naive and memory CD4+ T cells within the healthy human T-cell repertoire mediates HLA-restricted reactivity against autologous monocyte-derived dendritic cells which behave like a normal antigen-specific immune response. [Eur J Immunol] Abstract

IL-34- and M-CSF-Induced Macrophages Switch Memory T Cells into Th17 Cells via Membrane IL-1α
Scientists evaluated the capacity of human macrophages induced in the presence of M-CSF or IL-34 and ovarian cancer tumor-associated macrophages to modulate the phenotype of human CD4+ T cells. [Eur J Immunol] Abstract

IL-17 Induces Radiation Resistance of B Lymphoma Cells by Suppressing p53 Expression and Thereby Inhibiting Irradiation-Triggered Apoptosis
A human B lymphoma cell line, Karpas1106 (k1106), was used as a model of radioresistance. When k1106 cells were cocultured with regulatory T cells and irradiated, the rate of apoptotic k1106 cells was significantly reduced, indicating an acquired resistance to irradiation. [Cell Mol Immunol] Abstract

Generation of Tumor-Specific Cytotoxic T-Lymphocytes from the Peripheral Blood of Colorectal Cancer Patients for Adoptive T-Cell Transfer
Researchers designed a strategy for an ACT protocol based on the ex vivo selection of autologous peripheral blood-derived CD8-enriched T-cells, stimulated with dendritic cells that had been pulsed with apoptotic tumor cells to generate cytotoxic T lymphocytes with anti-tumor activity. [J Cell Physiol] Abstract

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Beyond Receptors and Signaling: Epigenetic Factors in the Regulation of Innate Immunity
Although signaling pathways and transcription factors have a central role, it is becoming increasingly clear that epigenetic factors are critical for generating the necessary cell lineage as well as context-specific gene expression in diverse innate immune cell types. The authors review the important contribution of epigenetic factors to the initiation, maintenance and training of innate immune responses. [Immunol Cell Biol] Abstract

Visit our reviews page to see a complete list of reviews in the human immunology research field.
New Liver Cancer Target Is a Protein that Accelerates Inflammation
A $1.6 million National Cancer Institute grant will help Dr. Anatolij Horuzsko and his team learn whether bringing down the curtain on TREM-1 blocks liver cancer development and possibly other inflammation-associated cancers such as colorectal, lung, and cervical cancer. [Georgia Regents University] Press Release

Isis Pharmaceuticals Announces Collaboration with Janssen to Discover and Develop RNA-Targeted Therapeutics for Autoimmune Diseases in the GI Tract
Isis Pharmaceuticals, Inc. announced that the company has entered into a global collaboration with Janssen Biotech, Inc. to discover and develop antisense drugs to treat autoimmune disorders of the gastrointestinal (GI) tract. [Isis Pharmaceuticals, Inc.] Press Release

Amgen and Kite Pharma Announce Strategic Cancer Immunotherapy Collaboration to Advance the Application of Novel Chimeric Antigen Receptor (CAR) T Cell Therapies
Amgen and Kite Pharma announced that the two companies have entered into a strategic research collaboration and license agreement to develop and commercialize the next generation of novel CAR T cell immunotherapies based on Kite’s engineered autologous cell therapy platform and Amgen’s extensive array of cancer targets. [Amgen Inc.] Press Release

Regulatory Approval of Novartis’ Cosentyx™ in Japan for Both Psoriasis and Psoriatic Arthritis
Novartis announced that the Japanese Ministry of Health, Labor and Welfare approved Cosentyx™ (secukinumab), for the treatment of both psoriasis vulgaris and psoriatic arthritis in adults who are not adequately responding to systemic therapies. [Novartis AG] Press Release

Bavarian Nordic Announces Initiation of Phase I Clinical Trial for the Ebola Vaccine Regimen of MVA-BN® Filo and Janssen’s AdVac® Technology
Bavarian Nordic A/S announced the initiation of a Phase I, first-in-human clinical trial of the preventative Ebola vaccine regimen consisting of MVA-BN® Filo and the AdVac® technology from Crucell Holland B.V., one of the Janssen Pharmaceutical Companies of Johnson & Johnson. [Bavarian Nordic A/S] Press Release

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European Medicines Agency (European Union)

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Therapeutic Goods Administration (Australia)
NEW Keystone Symposium – Co-Infection: A Global Challenge for Disease Control
March 15-20, 2015
Ouro Preto, Brazil

NEW European Academy of Allergy and Clinical Immunology (EAACI) Congress 2015
June 6-10, 2015
Barcelona, Spain

Visit our events page to see a complete list of events in the human immunology community.
NEW Tenure-Track Assistant Professor – Pathology (Stanford University School of Medicine)

NEW Senior Research Scientist – Immunohistochemistry (iTeos Therapeutics)

NEW Research Scientist – Cancer Immunotherapy (iTeos Therapeutics)

NEW Postdoctoral Research Fellow – Translational Immuno-Oncology (University Hospital Essen)

NEW Senior Medical Advisor – Inflammation & Immunology (Celgene Corporation)

Faculty Position – Department of Microbiology and Immunology (Indiana University School of Medicine)

Postdoctoral Fellow – Immunology (Hospital for Special Surgery)

Product Manager Global Marketing – Autoimmunity (Thermo Fisher Scientific)

Scientist – Recombinant Molecules and Antibodies (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

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