Volume 3.00 | Jan 6

Human Immunology News 3.00 January 6, 2015
Human Immunology News
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TOP STORY
mTOR Inhibition Improves Immune Function in the Elderly
To begin to assess the effects of mammalian target of rapamycin (mTOR) inhibition on human aging-related conditions, scientists evaluated whether the mTOR inhibitor RAD001 ameliorated immunosenescence in elderly volunteers, as assessed by their response to influenza vaccination. [Sci Transl Med] Abstract | Editorial
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PUBLICATIONS (Ranked by impact factor of the journal)
Syk Is Indispensable for CpG-Induced Activation and Differentiation of Human B Cells
Investigators describe a so far unidentified, spleen tyrosine kinase (Syk)-dependent pathway, which is indispensable for CpG-induced human B cell activation. They show that triggering of B cells by CpG results in Syk and src kinase phosphorylation, proliferation, as well as cytokine and antibody production independent of the BCR. [Cell Mol Life Sci] Abstract

CD26-Mediated Induction of EGR2 and IL-10 as Potential Regulatory Mechanism for CD26 Costimulatory Pathway
Scientists examined the expression of inhibitory molecules induced via CD26-mediated costimulation. They show that coengagement of CD3 and CD26 induces preferential production of IL-10 in human CD4+ T cells, mediated through NFAT and Raf-MEK-ERK pathways. [J Immunol] Abstract

Combination Therapy with Anti-CTLA-4 and Anti-PD-1 Leads to Distinct Immunologic Changes In Vivo
Investigators show that blockade of CTLA-4, PD-1, or combination of the two leads to distinct genomic and functional signatures in vivo in purified human T cells and monocytes. [J Immunol] Abstract

Induced Expression of FcγRIIIa (CD16a) on CD4+ T Cells Triggers Generation of IFN-γhigh Subset
The authors show that a subset of activated CD4+ T-cells in humans express FcγRIIIa. The ligation of FcγRIIIa by immune complexes in human CD4+ T-cells produced co-stimulatory signal like CD28 that triggered IFN-γ production. [J Biol Chem] Abstract | Full Article

Monocyte-Derived Dendritic Cells Can Induce Autoreactive CD4+ T Cells Showing Myeloid Lineage-Directed Reactivity in Healthy Individuals
Researchers show that a minority of naive and memory CD4+ T cells within the healthy human T-cell repertoire mediates HLA-restricted reactivity against autologous monocyte-derived dendritic cells which behave like a normal antigen-specific immune response. [Eur J Immunol] Abstract

IL-34- and M-CSF-Induced Macrophages Switch Memory T Cells into Th17 Cells via Membrane IL-1α
Scientists evaluated the capacity of human macrophages induced in the presence of M-CSF or IL-34 and ovarian cancer tumor-associated macrophages to modulate the phenotype of human CD4+ T cells. [Eur J Immunol] Abstract

IL-17 Induces Radiation Resistance of B Lymphoma Cells by Suppressing p53 Expression and Thereby Inhibiting Irradiation-Triggered Apoptosis
A human B lymphoma cell line, Karpas1106 (k1106), was used as a model of radioresistance. When k1106 cells were cocultured with regulatory T cells and irradiated, the rate of apoptotic k1106 cells was significantly reduced, indicating an acquired resistance to irradiation. [Cell Mol Immunol] Abstract

Generation of Tumor-Specific Cytotoxic T-Lymphocytes from the Peripheral Blood of Colorectal Cancer Patients for Adoptive T-Cell Transfer
Researchers designed a strategy for an ACT protocol based on the ex vivo selection of autologous peripheral blood-derived CD8-enriched T-cells, stimulated with dendritic cells that had been pulsed with apoptotic tumor cells to generate cytotoxic T lymphocytes with anti-tumor activity. [J Cell Physiol] Abstract

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REVIEWS
Beyond Receptors and Signaling: Epigenetic Factors in the Regulation of Innate Immunity
Although signaling pathways and transcription factors have a central role, it is becoming increasingly clear that epigenetic factors are critical for generating the necessary cell lineage as well as context-specific gene expression in diverse innate immune cell types. The authors review the important contribution of epigenetic factors to the initiation, maintenance and training of innate immune responses. [Immunol Cell Biol] Abstract

Visit our reviews page to see a complete list of reviews in the human immunology research field.
 
INDUSTRY NEWS
New Liver Cancer Target Is a Protein that Accelerates Inflammation
A $1.6 million National Cancer Institute grant will help Dr. Anatolij Horuzsko and his team learn whether bringing down the curtain on TREM-1 blocks liver cancer development and possibly other inflammation-associated cancers such as colorectal, lung, and cervical cancer. [Georgia Regents University] Press Release

Isis Pharmaceuticals Announces Collaboration with Janssen to Discover and Develop RNA-Targeted Therapeutics for Autoimmune Diseases in the GI Tract
Isis Pharmaceuticals, Inc. announced that the company has entered into a global collaboration with Janssen Biotech, Inc. to discover and develop antisense drugs to treat autoimmune disorders of the gastrointestinal (GI) tract. [Isis Pharmaceuticals, Inc.] Press Release

Amgen and Kite Pharma Announce Strategic Cancer Immunotherapy Collaboration to Advance the Application of Novel Chimeric Antigen Receptor (CAR) T Cell Therapies
Amgen and Kite Pharma announced that the two companies have entered into a strategic research collaboration and license agreement to develop and commercialize the next generation of novel CAR T cell immunotherapies based on Kite’s engineered autologous cell therapy platform and Amgen’s extensive array of cancer targets. [Amgen Inc.] Press Release

Regulatory Approval of Novartis’ Cosentyx™ in Japan for Both Psoriasis and Psoriatic Arthritis
Novartis announced that the Japanese Ministry of Health, Labor and Welfare approved Cosentyx™ (secukinumab), for the treatment of both psoriasis vulgaris and psoriatic arthritis in adults who are not adequately responding to systemic therapies. [Novartis AG] Press Release

Bavarian Nordic Announces Initiation of Phase I Clinical Trial for the Ebola Vaccine Regimen of MVA-BN® Filo and Janssen’s AdVac® Technology
Bavarian Nordic A/S announced the initiation of a Phase I, first-in-human clinical trial of the preventative Ebola vaccine regimen consisting of MVA-BN® Filo and the AdVac® technology from Crucell Holland B.V., one of the Janssen Pharmaceutical Companies of Johnson & Johnson. [Bavarian Nordic A/S] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Keystone Symposium – Co-Infection: A Global Challenge for Disease Control
March 15-20, 2015
Ouro Preto, Brazil

NEW European Academy of Allergy and Clinical Immunology (EAACI) Congress 2015
June 6-10, 2015
Barcelona, Spain

Visit our events page to see a complete list of events in the human immunology community.
 
JOB OPPORTUNITIES
NEW Tenure-Track Assistant Professor – Pathology (Stanford University School of Medicine)

NEW Senior Research Scientist – Immunohistochemistry (iTeos Therapeutics)

NEW Research Scientist – Cancer Immunotherapy (iTeos Therapeutics)

NEW Postdoctoral Research Fellow – Translational Immuno-Oncology (University Hospital Essen)

NEW Senior Medical Advisor – Inflammation & Immunology (Celgene Corporation)

Faculty Position – Department of Microbiology and Immunology (Indiana University School of Medicine)

Postdoctoral Fellow – Immunology (Hospital for Special Surgery)

Product Manager Global Marketing – Autoimmunity (Thermo Fisher Scientific)

Scientist – Recombinant Molecules and Antibodies (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)


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