Volume 2.38 | Oct 7

Human Immunology News 2.38 October 7, 2014
Human Immunology News
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miR-10a Inhibits Dendritic Cell Activation and Th1/Th17 Cell Immune Responses in IBD
Researchers investigated the role of microRNA (miR)-10a, a small, non-coding RNA, in the regulation of innate and adaptive responses to microbiota in IBD. [Gut] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Multiple Sclerosis-Associated ​IL2RA Polymorphism Controls ​GM-CSF Production in Human TH Cells
Scientists report association of granulocyte-macrophage colony-stimulating factor (​GM-CSF) expression by human T helper (TH) cells with multiple sclerosis disease severity. ​GM-CSF is strongly induced by ​interleukin 2. [Nat Commun] Abstract

A Major Population of Mucosal Memory CD4+ T Cells, Coexpressing IL-18Rα and DR3, Display Innate Lymphocyte Functionality
Researchers identified a major subset of memory CD4+ T cells at barrier surfaces that coexpress interleukin-18 receptor alpha (IL-18Rα) and death receptor-3 (DR3), and display innate lymphocyte functionality. [Mucosal Immunol] Full Article

CD4+Foxp3+ Regulatory T Cell Differentiation Mediated by Endometrial Stromal Cell-Derived TECK Promotes the Growth and Invasion of Endometriotic Lesions
The supernatant from co-cultured human endometrial stromal cells and macrophages not only induced regulatory T cells (Treg) differentiation and increased Treg expression of interleukin-10, transforming growth factor-β and CD73 by activating the AKT/STAT3 signaling pathway but also repressed Treg apoptosis by downregulating Fas and FasL expression and enhanced the Treg-mediated suppression of CD4+CD25 T cells. [Cell Death Dis] Full Article

Tubulin- and Actin-Associating GIMAP4 Is Required for IFN-γ Secretion during Th Cell Differentiation
Researchers discovered that GTPase of the immunity-associated protein (GIMAP)4 regulates secretion of cytokines in early differentiating human CD4+ T helper (Th) lymphocytes and in particular the secretion of interferon-γ (IFN-γ) also affecting its downstream targets. [Immunol Cell Biol] Full Article

IL-32γ Delays Spontaneous Apoptosis of Human Neutrophils through MCL-1, Regulated Primarily by the p38 MAPK Pathway
Researchers demonstrate that IL-32γ delays, in a dose-dependent manner, the spontaneous apoptosis of human blood neutrophils by activating mainly p38 MAPK through rapid p38 phosphorylation. [PLoS One]
Full Article

Elevation of MMP-9 and IDO Induced by Pancreatic Cancer Cells Mediates Natural Killer Cell Dysfunction
Natural killer (NK) cells isolated from fresh healthy peripheral blood were co-cultured with normal human pancreatic ductal cells hTERT-HPNE and human pancreatic cancer cell lines SW1990 and BxPc-3 in vitro. Then NK cell function was determined by flow cytometric analysis of surface receptors and cytotoxic granules in NK cells, NK cell apoptosis and cytotoxicity, and enzyme-linked immunosorbent assay of cytokines. [BMC Cancer] Abstract | Full Article

Inhibition of Human Natural Killer Cell Functional Activity by Human Aspartyl β-Hydroxylase
Scientists investigated the potential use of human aspartyl β-hydroxylase (HAAH) as an immune regulator of human natural killer (NK) cells. They assessed the effects of recombinant HAAH on primary human NK cell morphology, viability, cytotoxicity, apoptosis, receptors expression and cytokine/cytolytic proteins production. [Int Immunopharmacol] Abstract

Neutrophil:Lymphocyte Ratios and Serum Cytokine Changes after Hepatic Artery Chimeric Antigen Receptor-Modified T-Cell Infusions for Liver Metastases
A Phase I hepatic immunotherapy for metastases trial tested the safety of chimeric antigen receptor-modified T-cell hepatic artery infusions for unresectable carcinoembryonic antigen+ liver metastases. [Cancer Gene Ther] Abstract

The Effect of Glatiramer Acetate Therapy on Functional Properties of B Cells from Patients with Relapsing-Remitting Multiple Sclerosis
The authors describe what is the previously unknown effect of glatiramer acetate therapy on B cells in patients with relapsing-remitting multiple sclerosis. [JAMA Neurol] Abstract

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Autophagy in T-Cell Development, Activation and Differentiation
Autophagy is crucial for T-cell development at the precursor stage as self-renewability and quiescence of hematopoietic stem cells depend on autophagy of the mitochondria and the endoplasmic reticulum. Later, during development in the thymus, autophagy regulates peptide presentation in stromal cells and professional antigen-presenting cells, which mediate thymocyte selection. [Immunol Cell Biol] Abstract

Visit our reviews page to see a complete list of reviews in the human immunology research field.
Compugen Immune Checkpoint Results Being Presented at Three Scientific Conferences
Compugen Ltd. announced that certain aspects of its predictive approach to therapeutics discovery as applied to novel immune checkpoints will be presented in poster sessions at three leading scientific conferences this month and next. [Press release from Compugen Ltd. discussing research to be presented at various conferences] Press Release

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Horwitz Prize Awarded for Work on Therapy That Uses the Immune System to Destroy Cancer Cells
Columbia University will award the 2014 Louisa Gross Horwitz Prize to James P. Allison, PhD, of the University of Texas MD Anderson Cancer Center, for his work on understanding the process of T-cell activation and for developing therapies that harness the immune system to fight cancer. [Columbia University] Press Release

BioNTech AG and Ganymed Pharmaceuticals AG Open New Research Headquarters in Mainz, Germany
BioNTech AG and Ganymed Pharmaceuticals AG announced the joint-opening of a new approx. 10,000 square-meter headquarters and research facility. BioNTech and Ganymed scientists will work in state-of-the-art lab space on a range of pre-clinical and clinical programs mainly in the field of highly personalized cancer therapies. [BioNTech AG] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Digital Pathology Congress 2014
December 4-5, 2014
London, United Kingdom

NEW The Microbiome Forum: Asia 2015
January 19-20, 2015
Kuala Lumpur, Malaysia

NEW Biologics Congress 2015
February 2-3, 2015
Berlin, Germany

Visit our events page to see a complete list of events in the human immunology community.
NEW Faculty Positions – Immunology (Nanjing Medical University)

Postdoctoral Position – Immunometabolism (INSERM)

Senior Research Fellow – Immunosenescence and Immune Exhaustion in Persistent Infections and Aging (Singapore Immunology Network A*STAR)

Postdoctoral Fellow – Interleukin 23 in the Pathogenesis of Systemic Lupus Erythematosus (Beth Israel Medical Center)

Research Scientist – Immunology (Beijing Genomics Institute)

Postdoctoral Fellowship – Immunology (Huazhong University of Science and Technology)

Postdoctoral Position – Transplantation Aspects of Hepatocytes Derived from Human Pluripotent Stem Cells (INSERM UMR 1064 )

Postdoctoral Position – Human Mucosal Immunology (INSERM)

Scientist – Recombinant Molecules and Antibodies (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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