Natural (Born) Killer Cells Battle Pediatric Leukemia
Researchers have shown that a select team of immune-system cells from patients with leukemia can be multiplied in the lab, creating an army of natural killer cells that can be used to destroy the cancer cells. [Press release from Children’s Hospital Los Angeles discussing online prepublication in Leukemia] Press Release|Abstract
A Human Immunodeficiency Caused by Mutations in the PIK3R1 Gene
Scientists identified two different heterozygous splice site mutations that affect the same splice site in PIK3R1, which encodes the p85α subunit of PI3K. The hypothetical loss of p85α-mediated inhibition of p110 activity was supported by elevated phosphorylation of the known downstream signaling kinase AKT in patient T cell blasts. [J Clin Invest] Full Article
Tolerogenic Dendritic Cells and Their Applications in Transplantation
The authors focus on tolerogenic dendritic cells (tol-DCs) that have the potential to promote immune tolerance after solid-organ transplantation. They focus on their development and interactions with other regulatory cells and explore various tol-DC engineering protocols. [Cell Mol Immunol] Abstract
Targeting Th17 Cells in Autoimmune Diseases
The authors discuss the rationale for targeting two checkpoints in the development and inflammatory function of T helper 17 (Th17) cells, retinoid-related orphan receptor-γt (RORγt) and interleukin (IL)-23, and review recent progress in the development of both RORγt small molecule inhibitors and IL-23 neutralizing antibodies. [Trends Pharmacol Sci] Abstract
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Protagen AG Launches Landmark First Research Test Kit for Systemic Sclerosis
Protagen AG launched its first ELISA research use test kit for Systemic Sclerosis (SSc), the ADx®SSc Multilisa®. Protagen developed the new assay to synergistically combine two proprietary, novel disease markers with two standard diagnostic markers to support medical research in autoimmune diseases. [Protagen AG] Press Release
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