Volume 2.23 | Jun 17

Human Immunology News 2.23 June 17, 2014
Human Immunology News
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Brodalumab, an Anti-IL17RA Monoclonal Antibody, in Psoriatic Arthritis
Investigators assessed the efficacy and safety of brodalumab, a human monoclonal antibody against interleukin-17 receptor A (IL17RA), in a Phase II, randomized, double-blind, placebo-controlled study involving patients with psoriatic arthritis. [N Engl J Med] Abstract | Press Release
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PUBLICATIONS (Ranked by impact factor of the journal)
Association between CD8+ T-Cell Infiltration and Breast Cancer Survival in 12 439 Patients
T-cell infiltration in estrogen receptor-negative breast tumors has been associated with longer survival. To investigate this association and the potential of tumor T-cell infiltration as a prognostic and predictive marker, researchers conducted the largest study of T cells in breast cancer to date. [Ann Oncol]
Abstract | Press Release

Targeting WNT1-Inducible Signaling Pathway Protein 2 Alters Human Breast Cancer Cell Susceptibility to Specific Lysis through Regulation of KLF-4 and miR-7 Expression
Investigators found that silencing WNT1-inducible signaling pathway protein 2 signaling in human breast adenocarcinoma MCF7 cells impairs cytotoxic T-lymphocyte-mediated cell killing by a mechanism involving stem cell marker Kruppel-like factor-4 induction and microRNA-7 (miR-7) downregulation. [Oncogene] Abstract

A Role for CCL28-CCR3 in T-Cell Homing to the Human Upper Airway Mucosa
Analysis of the cognate chemokine receptors revealed that close to 50% of the CD4+ T cells in the human nasal mucosa expressed the CCL28 receptor CCR3, whereas CCR3 was hardly detectable on T cells in the small intestine and skin. In the circulation, CCR3+ T cells comprised a small subset that did not express homing receptors to the intestine or skin. [Mucosal Immunol] Abstract

Association between Group 2 Innate Lymphoid Cells Enrichment, Nasal Polyps and Allergy in Chronic Rhinosinusitis
Researchers characterized group 2 innate lymphoid cell (ILC2) compartment in chronic rhinosinusitis (CRS) by investigating the correlations between ILC2s, Th2 cells and Th2 cytokines expression in CRS patients. [Allergy] Abstract

A High Frequency of Myeloid-Derived Stem Cells (MDSCs) in Sepsis Patients, with the Granulocytic Subtype Dominating in Gram-Positive Cases
Investigators analyzed potential MDSCs in sepsis patients with different causative microorganisms, using total peripheral blood compared with density gradient-centrifuged blood. [J Leukoc Biol] Abstract

Upregulation of Store-Operated Ca2+ Entry in the Naïve CD4+ T Cells with Aberrant Cytokine Releasing in Active Rheumatoid Arthritis
Researchers measured Ca2+ influx and Ca2+ release-activated Ca2+ currents in naïve and memory CD4+ T cells. These cells were further characterized by flow cytometric analysis of interleukin (IL)-4, IL-17, interferon-γ and tumor necrosis factor-α. [Immunol Cell Biol] Abstract

Clinical Heterogeneity of Immunodysregulation, Polyendocrinopathy, Enteropathy, X-linked: Pulmonary Involvement as a Non-Classical Disease Manifestation
Immunodysregulation, Polyendocrinopathy, Enteropathy, X-linked is a rare X-linked recessive life-threatening disorder characterized by autoimmunity and early death. Clinical data and laboratory findings including autoantibodies, immunoglobulin levels as well as number of T, B and NK cells were evaluated. FOXP3 expression and T reg activity were analyzed. [J Clin Immunol] Abstract

Pre-TCRα Supports CD3-Dependent Reactivation and Expansion of TCRα-Deficient Primary Human T-Cells
Researchers showed that pre-T-cell receptor (TCR) α, a TCRα surrogate that pairs with TCRβ chains to signal proper TCRβ folding during T-cell development, can be expressed in TCRα knockout mature T-cells to support CD3 expression at the cell surface. [Mol Ther Methods Clin Dev] Full Article

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A New System for High-Throughput Cell Isolation Directly from Whole Blood
Social Networking of Human Neutrophils within the Immune System
Concepts such as “neutrophil heterogeneity” and “neutrophil plasticity” have started to emerge, implying that, under pathological conditions, neutrophils may differentiate into discrete subsets defined by distinct phenotypic and functional profiles. A number of studies have shown that neutrophils act as effectors in both innate and adaptive immunoregulatory networks. [Blood] Abstract

Orphan Nuclear Receptor NR2F6 Acts as an Essential Gatekeeper of Th17 CD4+ T Cell Effector Functions
A CD4+ T cell intrinsic and non-redundant function of NR2F6 as a potent and selective repressor of the transcription of the pro-inflammatory cytokines interleukin (Il) 2, interferon g, Il17 and Il21, and consequently of T helper (Th)17 CD4+ T cell-mediated autoimmune disorders has been discovered. [Cell Commun Signal]
Abstract | Full Article

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SMi present their inaugural conference on Immunogenicity
NeoStem Announces University of California, San Francisco Presentation of Phase I Results for T Regulatory Cell Immunotherapy for Type 1 Diabetes
NeoStem, Inc. announced the presentation of the results of an open-label dose escalation Phase I clinical study of autologous T regulatory cell immunotherapy for type 1 diabetes mellitus indicating safety and tolerability following administration. [Press release from NeoStem, Inc. discussing research presented at the American Diabetes Association 74th Scientific Sessions, San Francisco] Press Release

AVERT Trial Demonstrates High Rates of DAS-Defined Remission with Orencia® in Combination with Methotrexate in Adult Patients with Early Rheumatoid Arthritis
Bristol-Myers Squibb Company announced its first release of new data from a Phase IIIb rheumatoid arthritis (RA) trial showing that the T-cell co-stimulation modulator, Orencia®, in combination with methotrexate (MTX) achieved significantly higher rates of DAS-defined remission at 12 months than treatment with standard of care agent MTX in biologic and MTX-naïve patients with early active RA. [Press release from Bristol-Myers Squibb Company discussing research presented at the 2014 annual meeting of the European League Against Rheumatism (EULAR), Paris] Press Release | Abstract

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MorphoSys and Merck Serono Enter Strategic Immuno-Oncology Collaboration
MorphoSys AG and Merck announced that they have signed an agreement to discover and develop therapeutic antibodies against undisclosed immune checkpoints. Under the terms of the agreement, MorphoSys and Merck Serono will join forces to develop therapies that modulate the immune system’s natural ability to fight tumors. [MorphoSys AG] Press Release

Hyperion Therapeutics Completes Acquisition of Andromeda Biotech, Ltd.
Hyperion Therapeutics, Inc. announced that it has completed its acquisition of Andromeda Biotech Ltd. The acquisition broadens Hyperion’s pipeline to include DiaPep277®, a potentially first-in-class immunotherapy for new onset Type 1 diabetes. [Hyperion Therapeutics, Inc.] Press Release

Virginia G. Piper Cancer Center Vaccine Study Hopes to Improve Pancreatic Cancer Treatment
Medical investigators at the Virginia G. Piper Cancer Center at Scottsdale Healthcare are studying a new cancer immunotherapy to see if it can successfully help patients with advanced pancreatic cancer. [Translational Genomics Research Institute] Press Release

Grant Supports Innovative Immunotherapy Research at Baylor
Baylor College of Medicine, Texas Children’s Cancer Center and Center for Cell and Gene Therapy researcher Dr. Stephen Gottschalk has received a $250,000 Innovation Award from Alex’s Lemonade Stand Foundation to support his work to find innovative new treatments for childhood cancer. [Baylor College of Medicine] Press Release

First-of-Its-Kind Pediatric Research and Funding Collaboration to Speed Development of Medications for Autoimmune Diseases
Seattle Children’s Research Institute and Kineta, Inc. launched the Alliance for Children’s Therapeutics, a first-of-its-kind pediatric research and funding collaboration designed to speed development of new medications for children and teens with lupus nephritis and other autoimmune diseases like multiple sclerosis, Type 1 diabetes and rheumatoid arthritis. [Seattle Children’s Research Institute] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 13th International Symposium on Dendritic Cells
September 14-18, 2014
Loire Valley, France

Visit our events page to see a complete list of events in the human immunology community.
NEW Postdoctoral Scientist – Immune Focused In Vitro Analytics (Celentyx Ltd.)

NEW Research Scientist – Autoimmunity (Eli Lilly)

NEW Postdoctoral Positions – Cancer Immunology (Cold Spring Harbor Laboratory)

PhD Candidate – Tumor Immunology and Cell Signaling (Goethe University Frankfurt)

Postdoctoral Positions – Epigenetics in Autoimmune Diseases (Weill Cornell Medical School/Memorial Sloan Kettering Cancer Center)

Postdoctoral Fellow – Immunology (Charité – Universitätsmedizin Berlin)

Research Associate – Cellular Immunology (Alector LLC)

PhD Candidate – Immune Monitoring (Erasmus MC)

PhD Studentship – Characterization of Human Antibodies Removed from the Repertoire in Central Tolerance (King’s College London)

Principal Investigator – Molecular Mechanisms of Inflammation (Inflammation Research Center – VIB-UGent)

PhD Research Position – Immune Tolerance and Autoimmunity (Weizmann Institute of Science)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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