Human Immunology News

Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.

Safety and Immunogenicity of a Novel Trivalent Recombinant MVA-Based Equine Encephalitis Virus Vaccine: A Phase 1 Clinical Trial

[Vaccine] A novel multivalent MVA-BN-WEV vaccine encodes the envelope surface proteins of the 3 viruses and is thereby potentially able to protect against three encephalitic alphaviruses. This first-in-human study assessed the safety, tolerability, and immunogenicity of MVA-BN-WEV vaccine in healthy adult participants.

Evidence for Antigen Presentation by Human Neutrophils

[Blood] Investigators found that the human cells were clearly able to up-regulate HLA-DR and co-stimulatory molecules; were able to process protein antigen into fragments recognized by T cells; could enter lymph node T cell zones; and, in vitro, were able to present antigen to memory T cells, inducing proliferation and cytokine production.

Th1 Cell Immune Response in Talaromyces marneffei Infection with Anti-Interferon-γ Autoantibody Syndrome

[Microbiology Spectrum] A multicenter study of HIV-negative individuals with T. marneffei infection was conducted between September 2018 and September 2020 in Guangdong and Guangxi, China. Patients were divided into anti-interferon-γ autoantibody (AIGA)-positive and AIGA-negative groups according to the AIGA titer and neutralizing activity.

Human Bronchial Epithelial Cell Transcriptome Changes in Response to Serum from Patients with Different Status of Inflammation

[Lung] Researchers investigated the transcriptome of human bronchial epithelial cells in response to serum from patients with different degrees of inflammation. Serum from 19 COVID-19 patients obtained from the Hannover Unified Biobank was used.

Raman Spectroscopy of Lymphocytes from Patients with the Epstein–Barr Virus Infection

[Scientific Reports] Raman spectroscopy was applied to trace lymphocytes activation following contact with the Epstein–Barr virus of the herpesvirus family. The biomarker of cell activation was found to be the 520 cm−1 band, indicating the formation of immunoglobulins.

Adipose Stem Cells Control Obesity-Induced T Cell Infiltration into Adipose Tissue

[Cell Reports] Scientists underscored the pivotal role of adipose stem cellss in regulating T cell accumulation in white adipose tissue during the early phases of obesity, emphasizing their importance in modulating adaptive immunity in obesity-induced adipose inflammation.

Blood-Based Biomarkers in Patients with Non-small Cell Lung Cancer Treated with Immune Checkpoint Blockade

[Journal Of Experimental & Clinical Cancer Research] The authors review studies in which multiple blood-based biomarkers encompassing circulating soluble analytes, immune cell subsets, circulating tumor DNA, blood-based tumor mutational burden, and circulating tumor cells have shown promising associations with the clinical response of non-small cell lung cancer patients to immune checkpoint inhibitors therapy.

TaiMed Biologics and AcedrA BioPharmaceuticals Partner to Commercialize Trogarzo® (Ibalizumab-uiyk) in the Middle East and North Africa Region

[TaiMed Biologics (Globe Newswire)] TaiMed Biologics signed an Exclusive License and Distribution Agreement with AcedrA BioPharmaceuticals (“AcedrA”), a Saudi Arabia-based company operating in Middle East and North Africa region, to satisfy the unmet medical needs, under which AcedrA will register, promote and commercialize Trogarzo® (Ibalizumab-uiyk) in the MENA region.

Upregulation of HLA-II Related to LAG-3+ CD4+ T Cell Infiltration Is Associated with Patient Outcome in Human Glioblastoma

[Cancer Science] Scientists investigated the expression and regulation of human leukocyte antigen-II in human glioblastoma samples and the correlation with LAG-3+CD4+ T cell infiltration.

Preclinical and Translational Pharmacology of Afucosylated Anti-CCR8 Antibody for Depletion of Tumour-Infiltrating Regulatory T Cells

[Oncoimmunology] Researchers described that cancer cell-neutrophil signaling circuitry provokes neutrophil-derived transmembrane TNF-TNFR2 interactions that dictate inflammatory polarization in cancer-associated fibroblasts and T cell dysfunction – two hallmarks of therapeutic resistance.

Antibody-Independent Protection Against Heterologous SARS-CoV-2 Challenge Conferred by Prior Infection or Vaccination

[Nature Immunology] Researchers showed, through studies in mouse models lacking antibodies but maintaining functional B cells and lymphoid organs, that immunity conferred by prior infection or mRNA vaccination can protect against SARS-CoV-2 challenge independently of antibodies.

Tumor-Infiltrating Lymphocytes Refine Outcomes in Triple-Negative Breast Cancer Treated with Anthracycline-Free Neoadjuvant Chemotherapy

[Clinical Cancer Research] Scientists highlighted the role of stromal tumor-infiltrating lymphocytes in patient selection/stratification for neo/adjuvant escalation and de-escalation strategies.

Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.

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