Volume 2.22 | Jun 10

Human Immunology News 2.22 June 10, 2014
Human Immunology News
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TOP STORY
Human B Cells Induce Dendritic Cell Maturation and Favor Th2 Polarization by Inducing OX-40 Ligand
Various reports demonstrated that B cells have profound regulatory functions, although only few reports have explored the regulation of human dendritic cells (DCs) by B cells. Investigators demonstrate that activated but not resting B cells induce maturation of DCs with distinct features to polarize Th2 cells that secrete interleukin (IL)-5, IL-4 and IL-13. [Nat Commun] Abstract
Free Nature Reviews Immunology Poster: The Immune Response to HIV
 
PUBLICATIONS (Ranked by impact factor of the journal)
Sirolimus-Based Graft-versus-Host Disease Prophylaxis Promotes the In Vivo Expansion of Regulatory T Cells and Permits Peripheral Blood Stem Cell Transplantation from Haploidentical Donors
Scientists explored in 121 patients, mostly with advanced stage diseases, a sirolimus-based, calcineurin-inhibitor-free prophylaxis of graft-versus-host disease to allow the infusion of unmanipulated peripheral blood stem cell grafts from partially HLA-matched family donors. [Leukemia] Abstract

Human Memory T Cells from the Bone Marrow Are Resting and Maintain Long-Lasting Systemic Memory
Researchers showed that human bone marrow professional memory T cells are not activated but are resting in terms of proliferation, transcription, and mobility. [Proc Natl Acad Sci USA] Abstract

Abnormally Differentiated CD4+ or CD8+ T-Cells with Phenotypic and Genetic Features of Double Negative T-Cells in Human Fas Deficiency
Researchers showed that human autoimmune lymphoproliferative syndrome (ALPS) double negative T cells have features of terminally differentiated effector memory CD45RA+ (TREMA) cells, but are CD27+CD28+KLRG1 and do not express the transcription factor T-bet. This unique phenotype was also detected among CD4+ or CD8+ ALPS TEMRA cells. [Blood] Abstract

IL-1β Promotes the Differentiation of Polyfunctional Human CCR6+CXCR3+ Th1/17 Cells That Are Specific for Pathogenic and Commensal Microbes
Scientists examined CCR6+CXCR3+ Th1/17 cells from healthy individuals and found that ex vivo these cells produced the effector cytokines IL-17, IL-22, and IFN-γ in all possible combinations and were highly responsive to both IL-12 and IL-23. [J Immunol] Abstract

Hemin Controls T Cell Polarization in Sickle Cell Alloimmunization
Because monocytes play a critical role in polarization of T cell subsets and participate in clearance of transfused RBCs, investigators tested the hypothesis that in response to the RBC breakdown product hemin, monocyte control of T cell polarization will differ between alloimmunized and non-alloimmunized sickle cell disease patients. [J Immunol] Abstract

Granulocytic Myeloid-Derived Suppressor Cells Expand in Human Pregnancy and Modulate T-Cell Responses
Scientists demonstrate that myeloid-derived suppressor cells (MDSCs) with a granulocytic phenotype are highly increased in the peripheral blood of healthy pregnant women during all stages of pregnancy compared with non-pregnant controls, whereas numbers of monocytic MDSCs were unchanged. [Eur J Immunol] Abstract

Human Renal Fibroblasts Generate Dendritic Cells with a Unique Regulatory Profile
Researchers investigated whether renal fibroblasts influence human dendritic cell generation and function. They found that co-culture with renal fibroblasts led to the generation of monocyte-derived dendritic cells with significantly reduced CD80, CD83 and CD86 but elevated B7H1 and B7DC expression. [Immunol Cell Biol] Abstract

Intense Foxp3+CD25+ Regulatory T Cell Infiltration Is Associated with High-Grade Cutaneous Squamous Cell Carcinoma and Counterbalanced by CD8+/Foxp3+CD25+ Ratio
Researchers evaluated the content and distribution of Foxp3+CD25+ regulatory T and CD123+ plasmacytoid dendritic cells infiltration and assessed CD8+/Foxp3+CD25+ cell ratio at peritumoral and intratumoral levels in 40 squamous cell carcinomas (20 well-differentiated G1, and 20 moderately- to poorly-differentiated G2-G3) to evidence a correlation with their aggressiveness. [Br J Dermatol] Abstract

Intrinsically De-Sialylated CD103+ CD8 T Cells Mediate Beneficial Anti-Glioma Immune Responses
Investigators showed by flow cytometry that murine and human CD103+ CD8 T cells respond better than their CD103 counterparts to tumor peptide-MHC I stimulation in vitro and to tumor antigens on gliomas in vivo. [Cancer Immunol Immunother] Abstract

Interleukin-37 Mediates the Antitumor Activity in Hepatocellular Carcinoma: Role for CD57+ NK Cells
Interleukin (IL)-37 expression in tumor tissues was positively associated with the density of tumor-infiltrating CD57+ natural killer (NK) cells, but not with the CD3+ and CD8+ T cells. Consistently, in vitro chemotaxis analysis showed that IL-37- overexpressing hepatocellular carcinoma cells could recruit more NK cells. [Sci Rep] Full Article

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REVIEWS
Tumor-Infiltrating Lymphocyte Therapy for Melanoma: Rationale and Issues for Further Clinical Development
The authors summarize the current approaches and clinical data in the field of adoptive T-cell transfer therapy using tumor-infiltrating lymphocytes for metastatic melanoma. [BioDrugs] Abstract

Dendritic Cell Therapy in an Allogeneic-Hematopoietic Cell Transplantation Setting: An Effective Strategy toward Better Disease Control?
Authors focus on the use of dendritic cell (DC) vaccination to prevent cancer relapses early after allo-hematopoietic cell transplantation. They describe the role of host and donor-DCs, various vaccination strategies, different DC subsets, antigen loading, DC maturation/activation, and injection sites and dose. [Front Immunol] Full Article

Visit our reviews page to see a complete list of reviews in the human immunology research field.

Microbiology and Infectious Disease Congress 2014
 
SCIENCE NEWS
Caris Life Sciences Research Provides Key Clinical Insights on Immunotherapeutic Targets in a Broad Range of Cancers
Caris Life Sciences® announced the presentation of data from multiple studies in which Caris Molecular Intelligence™ was used to identify biomarkers of response to novel classes of immunotherapeutic agents. [Press release from Caris Life Sciences, Ltd. discussing research presented at the 50th Annual Meeting of the American Society of Clinical Oncology (ASCO), Chicago] Press Release

Immune Therapy for Advanced Bladder Cancer Yields Promising Results
A multi-center phase I study using an investigational drug for advanced bladder cancer patients who did not respond to other treatments has shown promising results in patients with certain tumor types, researchers report. [Press release from Yale University discussing research presented at the 50th Annual Meeting of the American Society of Clinical Oncology (ASCO), Chicago] Press Release

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INDUSTRY NEWS
Immunomedics Announces Orphan Drug Designation for IMMU-132 for Pancreatic Cancer Therapy
Immunomedics, Inc. announced that IMMU-132, the company’s antibody-drug conjugate for solid cancer therapy, has received orphan drug status from the Office of Orphan Products Development of the US Food and Drug Administration for the treatment of pancreatic cancer. [Immunomedics, Inc.] Press Release

Batu Biologics Announces FDA Development Plans for ValloVax™ Angiogenesis-Targeting Cancer Vaccine
Batu Biologics announced FDA development plans for its patent-pending lead product, ValloVax™, a cancer immunotherapeutic “vaccine” that specifically targets the tumor blood vessels. [Business Wire] Press Release

Antitope and Baylor Institute for Immunology Research to Collaborate to Produce Manufacturing Cell Line for Novel Therapeutic Dendritic-Cell-Targeting Vaccine
Baylor Institute for Immunology Research (BIIR) is developing a range of therapeutic vaccines for the treatment of cancer and other diseases, and Antitope will develop a cell line for the production of BIIR’s novel dendritic-cell-targeting vaccine for the treatment of head and neck and cervical cancer. [Abzena, Ltd.] Press Release

Kite Pharma Announces Exclusive License with the National Institutes of Health for T Cell Receptor-Based Products Targeting NY-ESO-1 for Multiple Cancer Indications
Kite Pharma, Inc. announced that it has entered into an exclusive, worldwide license with the National Institutes of Health to certain intellectual property related to T cell receptor-based product candidates that target the NY-ESO-1 antigen for the treatment of cancers expressing NY-ESO-1. [Kite Pharma, Inc.] Press Release

Immune Design Announces Treatment of First Patient in Phase I Clinical Trial of LV305 Immuno-Oncology Agent
Immune Design announced treatment of the first patient in a Phase I clinical trial of LV305, an immuno-oncology investigational agent from the company’s DCVex™ lentiviral vector platform. [Immune Design Corp] Press Release
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 44th Annual Meeting German Society for Immunology
September 17-20, 2014
Bonn, Germany

Visit our events page to see a complete list of events in the human immunology community.
 
JOB OPPORTUNITIES
NEW PhD Candidate – Tumor Immunology and Cell Signaling (Goethe University Frankfurt)

Cell Biologists – T Cell-Based Therapies (Adaptimmune)

Postdoctoral Positions – Epigenetics in Autoimmune Diseases (Weill Cornell Medical School/Memorial Sloan Kettering Cancer Center)

Senior Scientist – Immunology (Alector LLC)

Postdoctoral Fellow – Immunology (Charité – Universitätsmedizin Berlin)

Research Associate – Cellular Immunology (Alector LLC)

PhD Candidate – Immune Monitoring (Erasmus MC)

Postdoctoral Scholar – Cancer Research (University of Chicago)

PhD Studentship – Characterization of Human Antibodies Removed from the Repertoire in Central Tolerance (King’s College London)

Principal Investigator – Molecular Mechanisms of Inflammation (Inflammation Research Center – VIB-UGent)

Postdoctoral Fellow – Systemic Autoimmunity (Oklahoma Medical Research Foundation)

PhD Research Position – Immune Tolerance and Autoimmunity (Weizmann Institute of Science)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)


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