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New Study Offers ‘Tremendous Hope’ for Allergic Asthma Sufferers
Investigators found that giving a mild allergic asthma patient an antibody – which blocks a specific protein in the lungs – significantly improves symptoms such as wheezing, breathlessness, chest tightness and coughing after patients had inhaled an environmental allergen. [Press release from McMaster University discussing online prepublication in The New England Journal of Medicine]
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| | | PUBLICATIONS (Ranked by impact factor of the journal) |
Ipilimumab versus Placebo after Radiotherapy in Patients with Metastatic Castration-Resistant Prostate Cancer That Had Progressed after Docetaxel Chemotherapy (CA184-043): A Multicenter, Randomized, Double-Blind, Phase III Trial
Ipilimumab is a fully human monoclonal antibody that binds cytotoxic T-lymphocyte antigen 4 to enhance antitumor immunity. Scientists assessed the use of ipilimumab after radiotherapy in patients with metastatic castration-resistant prostate cancer that progressed after docetaxel chemotherapy. [Lancet Oncol]
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Press Release
IL-15.IL-15Rα Complex Shedding following Trans-Presentation Is Essential for the Survival of IL-15 Responding Natural Killer and T Cells
Investigators define an unprecedented cytokine pathway in which the interleukin (IL)-15.IL-15Rα complex cleaved from presenting cells allows responding cells to internalize, store and use IL-15.IL-15Rα complex for their own proliferation and survival. [Proc Natl Acad Sci USA]
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Increased Mitochondrial Apoptotic Priming of Human Regulatory T Cells after Allogeneic Hematopoietic Stem Cell Transplantation
Quantitation of mitochondrial apoptotic priming was used to compare susceptibility of regulatory T cells, conventional CD4 T cells and CD8 T cells to intrinsic pathway apoptosis in 57 patients after allogeneic hematopoietic stem cell transplantation and 25 healthy donors. [Haematologica]
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MiRNome and Transcriptome Aided Pathway Analysis in Human Regulatory T Cells
Scientists simultaneously analyzed miR and mRNA transcript levels in resting and activated human regulatory T cells in comparison with non-regulatory conventional T cells. [Genes Immun]
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Enterococcus faecalis from Healthy Infants Modulates Inflammation through MAPK Signaling Pathways
Investigators demonstrated that E. faecalis, isolated from healthy newborns, suppress inflammatory responses activated in vivo and in vitro. They found E. faecalis attenuates proinflammatory cytokine secretions, especially interleukin-8, through JNK and p38 signaling pathways. [PLoS One]
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Human Lung Epithelial Cells Contain Mycobacterium tuberculosis in a Late Endosomal Vacuole and Are Efficiently Recognized by CD8+ T Cells
Researchers demonstrated that airway epithelial cells efficiently stimulate interferon gamma release by M. tuberculosis-reactive CD8+ T cells as well as HLA-B45 and HLA-E restricted T cell clones. [PLoS One]
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Reconstitution of Regulatory T-Cell Subsets after Allogeneic Hematopoietic SCT
The reconstitution of total and subsets of regulatory T cells (Tregs) was prospectively analyzed by flow cytometry in 185 consecutive recipients at 3, 6, 12 and 24 months after allogeneic hematopoietic stem cell transplantation (SCT). The levels of total, naive and memory Tregs increased, mainly within the memory subset, but remained lower than healthy controls up to 2 years after transplantation. [Bone Marrow Transplant]
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The CD4 T Cell Response to Respiratory Syncytial Virus Infection
Prior immunization with a formalin-inactivated (FI-RSV) vaccine resulted in enhanced disease in infants following a natural respiratory syncytial virus (RSV) infection. A T helper 2 CD4 T cell response has been implicated to be a major contributor in mediating vaccine-enhanced disease. [Immunol Res]
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Expression and Effects of High-Mobility Group Box 1 in Cervical Cancer
Researchers investigated the significance of high-mobility group box1 (HMGB1) and T-cell-mediated immunity and prognostic value in cervical cancer. HMGB1, forkhead/winged helix transcription factor p3, interleukin (IL)-2, and IL-10 protein expression was analyzed in 100 cervical tissue samples including cervical cancer, cervical intraepithelial neoplasia, and healthy control samples using immunohistochemistry. [Int J Mol Sci]
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| REVIEWS |
Emerging Role of IL-17 and Th17 Cells in Systemic Lupus Erythematosus
IL-17 blockers have moved successfully into the clinical space, as illustrated in psoriasis and ankylosing spondylitis. However, recent fundamental studies highlighted unexpected aspects of IL-17/Th17 biology whose comprehension may prevent disappointing results of IL-17 targeting such as those obtained in Crohn’s disease. [Clin Immunol]
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