Volume 2.10 | Mar 18

Human Immunology News 2.10 March 18, 2014
Human Immunology News
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Bruton Tyrosine Kinase Mediates TLR9-Dependent Human Dendritic Cell Activation
Scientists investigated the role of bruton tyrosine kinase in human dendritic cell (DC) activation upon toll-like receptor 9 (TLR9) stimulation. DCs of patients with X-linked agammaglobulinemia and healthy donors were stimulated via TLR 4/9 and evaluated for cell activation and cytokine production. [J Allergy Clin Immunol] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
IgM Rheumatoid Factor Amplifies the Inflammatory Response of Macrophages Induced by the Rheumatoid Arthritis-Specific Immune Complexes Containing Anticitrullinated Protein Antibodies
Since IgM rheumatoid factor, an autoantibody directed to the Fc fragment of IgG, is also produced and concentrated in the rheumatoid synovial tissue, researchers evaluated its influence on macrophage stimulation by immune complexes containing IgG anticitrullinated protein antibodies. [Ann Rheum Dis] Abstract

Enhanced Glucocorticoid-Induced Leucine Zipper in Dendritic Cells Induces Allergen-Specific Regulatory CD4+T-Cells in Respiratory Allergies
Scientists suspect a defective expression of glucocorticoid-induced leucine zipper protein in the dendritic cells of respiratory allergic patients and speculate that increasing its expression might restore immune tolerance against allergens through the induction of IL-10-secreting regulatory CD4+T-cells. [Allergy] Abstract

Killer-Cell Immunoglobulin-Like Receptor Expression on Lymphocyte Subsets in Multiple Sclerosis Patients Treated with Interferon-β: Evaluation as Biomarkers for Clinical Response
Investigators analyzed whether the expression of killer-cell immunoglobulin-like receptor isoforms is implicated in multiple sclerosis pathogenesis and in the therapeutic response to interferon-β. [CNS Drugs] Abstract

Angiotensin Receptor Type 1 and Endothelin Receptor Type A on Immune Cells Mediate Migration and the Expression of Interleukin-8 and CCL18 When Stimulated by Autoantibodies from Systemic Sclerosis Patients
Angiotensin II receptor type 1 and endothelin receptor type A protein expression on peripheral blood mononuclear cells (PBMCs) from healthy individuals and systemic sclerosis patients were analyzed using flow cytometry, and mRNA expression of both receptors in PBMCs from healthy donors was examined by real-time PCR. [Arthritis Res Ther] Abstract | Full Article

Mitochondrial Dysfunction Promotes and Aggravates the Inflammatory Response in Normal Human Synoviocytes
The authors investigated whether mitochondrial dysfunction induces inflammatory responses in cultured normal human synoviocytes, a hallmark of rheumatoid arthritis. [Rheumatology] Abstract

Effects of IL-6 and IL-6 Blockade on Neutrophil Function In Vitro and In Vivo
Scientists investigated interactions between IL-6, the anti-IL-6 receptor agent tocilizumab (TCZ) and neutrophils in vitro and in vivo. Neutrophils were isolated from healthy controls and incubated in vitro with pharmacologically relevant concentrations of IL-6 or TCZ. [Rheumatology] Abstract

Natural Killer Cell-Mediated Shedding of ULBP2
Researchers showed that human tumor cells lost their surface expression of UL16 binding protein 2 (ULBP2), but not ULBP1 and ULBP3, during natural killer cell-mediated cytolysis. [PLoS One] Full Article

ATG16L1 and NOD2 Polymorphisms Enhance Phagocytosis in Monocytes of Crohn’s Disease Patients
Scientists assessed the differential responses in phagocytosis by measuring the phagocytic activity and the percentage of active phagocytic monocytes and granulocytes in inflammatory bowel disease patients as well as healthy controls. [World J Gastroentero] Full Article

RNA-Sequencing Methods for Identifying Differentially Expressed Gene in Human Pancreatic Islet Cells Treated with Pro-Inflammatory Cytokines
The authors profiled the transcriptome in human islets of langerhans under control conditions or following exposure to the pro-inflammatory cytokines based on the RNA sequencing dataset downloaded from SRA database. [Mol Biol Rep] Abstract

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The Immunology of Food Allergy
This review outlines the current understanding of how the immune system is thought to contribute to prevention or development of food allergies. [J Immunol] Abstract

Molecular Abnormalities of the B Cell in Systemic Lupus Erythematosus Are Candidates for Functional Inhibition Treatments
The authors focus on the aberrant phenotype of B cell signaling in patients with lupus. They also discuss data stemming from the use of small molecules that have recently been recognized to target important steps of the B cell signal transduction pathways with therapeutic implications for systemic lupus erythematosus. [Expert Opin Pharmacother] Abstract

Regulatory T-Cell Vaccination Independent of Auto-Antigen
This review article examines the potential of treating autoimmune diseases without having previous knowledge of the auto-anitgen using an innocuous antigen to stimulate regulatory T cells via the production of transforming growth factor-β and interleukin-10. [Exp Mol Med] Full Article

Visit our reviews page to see a complete list of reviews in the human immunology research field.

Attend Microbiology & Infectious Diseases Asia Congress in Singapore
Advaxis and UC San Francisco to Evaluate Cancer Immunotherapy Constructs in Prostate Cancer
Advaxis, Inc. announced that it has signed an agreement with the University of California, San Francisco, under which Lawrence Fong, M.D. will evaluate several new immunotherapy constructs, in addition to ADXS-PSA, each built on the Advaxis proprietary technology. [Advaxis, Inc.] Press Release

Tesaro and Anaptysbio Announce Collaboration and Exclusive Worldwide License Agreement for Multiple Immuno-Oncology Programs
TESARO, Inc. and AnaptysBio, Inc. announced an exclusive, worldwide license agreement and immuno-oncology antibody collaboration. Therapeutic antibodies selected from these programs will form the basis of a strategic platform that will enable TESARO to develop novel monotherapy and combination-based approaches with immuno-oncology and other anti-cancer agents in a variety of indications. [TESARO, Inc.] Press Release

MD Anderson, MedImmune Join Forces to Advance Cancer Immunotherapy
The University of Texas MD Anderson Cancer Center and MedImmune will collaborate through MD Anderson’s Moon Shots Program to develop therapies that unleash patients’ immune systems to attack their cancers. [The University of Texas MD Anderson Cancer Center] Press Release

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Alliance for Regenerative Medicine Announces Introduction of Regenerative Medicine Promotion Act of 2014 in the Senate
The Alliance for Regenerative Medicine announced the introduction of the Regenerative Medicine Promotion Act of 2014 in the U.S. Senate and expressed appreciation for the efforts of its lead sponsors, Senators Barbara Boxer and Mark Kirk. [Alliance for Regenerative Medicine] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW Vaccine Research Summit 2014
April 22-23, 2014
London, United Kingdom

Visit our events page to see a complete list of events in the human immunology community.
NEW Researcher – Effects of Immune-Modulating Therapy in Patients with Rheumatic Autoimmune Diseases (Sapienza Università di Roma)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Postdoctoral Fellowship – Construction of Vaccine Molecules for Treatment of Allergic Diseases (University of Oslo)

Postdoctoral Fellow Position – Examining the Impact of the Neonatal Immune System on Perinatal Brain Injury (University of Gothenburg)

Assistant/Associate Professors – Allergic Inflammation and Sensory Neurobiology (North Carolina State University College of Veterinary Medicine)

Postdoctoral Position – Epigenetic Regulation of Interleukin-12 Family Members (Université Libre de Bruxelles)

PhD Research Position – Immune Tolerance and Autoimmunity (Weizmann Institute of Science)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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