|PUBLICATIONS (Ranked by impact factor of the journal)|
| Autosomal Recessive Phosphoglucomutase 3 (PGM3) Mutations Link Glycosylation Defects to Atopy, Immune Deficiency, Autoimmunity, and Neurocognitive Impairment|
Researchers sought to define a genetic syndrome of severe atopy, increased serum IgE levels, immune deficiency, autoimmunity, and motor and neurocognitive impairment. [J Allergy Clin Immun]
Abstract | Press Release
Quantitative Reconstruction of Leukocyte Subsets Using DNA Methylation
Investigators developed an approach that uses DNA methylation to simultaneously quantify multiple leukocyte subsets, enabling the investigation of immune modulations in virtually any blood sample including archived samples previously precluded from such analysis. Here they assessed the performance characteristics and validity of this approach. [Genome Biol]Abstract | Full Article | Press Release
Enhancement of T Cell Responses as a Result of Synergy between Lower Doses of Radiation and T Cell Stimulation
Scientists report enhanced T cell function induced by synergistic radiation treatment, with potential physiological significance in a wide range of T cell responses. [J Immunol]Abstract
T Helper 17 Cell Cytokines and Interferon Type I: Partners in Crime in Systemic Lupus Erythematosus?
Recently, T helper 17 subset (Th17 cells), which produces IL-17A, IL-17F, IL-21 and IL-22, has been implicated in systemic lupus erythematosus (SLE). As CCR6 enriches for Th17 cells, researchers used this approach to investigate whether CCR6+ memory T helper cells producing IL-17A, IL-17F, IL-21 and/or IL-22 are increased in SLE patients and whether this increase is related to the presence of interferon type I signature. [Arthritis Res Ther]Abstract | Full Article
Ex Vivo Expanded Human Regulatory T Cells Delay Islet Allograft Rejection via Inhibiting Islet-Derived Monocyte Chemoattractant Protein-1 Production in CD34+ Stem Cells-Reconstituted NOD-scid IL2rγnull Mice
Investigators developed a pre-clinical model of human islet transplantation by reconstituting NOD-scid IL2rγnull mice with cord blood-derived human CD34+ stem cells and demonstrated that although the engrafted human immune system mediated the rejection of human islets, their survival was significantly prolonged following adoptive transfer of ex vivo expanded human regulatory T cells. [PLoS One]Full Article
Preferential Infiltration of IL-4-Producing CXCR4+ T Cells in the Lesional Muscle but Not Skin of Patients with Dermatomyositis
To investigate the difference between muscle- and skin-infiltrating T cells and to address their role for myopathy, researchers characterized T cells that were directly expanded from the tissues. [Clin Exp Immunol]Abstract
Luteinizing Hormone Contributes to Fetal Tolerance by Regulating Adaptive Immune Responses
Recently, the authors showed that human chorionic gonadotropin not only increases the number and activity of regulatory T cells (Treg) but also retains tolerogenic dendritic cells (DCs). Here, they investigated whether the highly homologous luteinizing hormone modulates Treg number and DC phenotype and thereby supports pregnancy. [Am J Reprod Immunol]Abstract
Allogeneic Lymphocyte-Licensed Dendritic Cells Expand T Cells with Improved Antitumor Activity and Resistance to Oxidative Stress and Immunosuppressive Factors
Scientists demonstrated that when irradiated and preactivated allosensitized allogeneic lymphocytes are used as helper cells to license OKT3-armed allogeneic mature dendritic cells, together they expand target T cells of high quality. [Mol Ther – Methods Clin Dev]Full Article | Press Release
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| Sanofi and UCB Partner for Breakthrough Innovation in Immune-Mediated Diseases |
Sanofi and UCB announced they have entered into a scientific and strategic collaboration for the discovery and development of innovative anti-inflammatory small molecules, which have the potential to treat a wide range of immune-mediated diseases in areas such as gastroenterology and arthritis. [Sanofi]Press Release
Synthetic Biologics Announces Issuance of U.S. Patent Adding Another Layer of Protection for the Use of Oral Estriol Candidate, Trimesta™, for Multiple Sclerosis
Synthetic Biologics, Inc. announced that the U.S. Patent & Trademark Office has issued U.S. Patent No. 8,658,627 entitled, “Pregnancy Hormone Combination for Treatment of Autoimmune Diseases”, to the Regents of the University of California. [Synthetic Biologics, Inc.]Press Release
Genocea Biosciences Announces Collaboration to Characterize T Cell Responses to Cancer Antigens
Genocea Biosciences, Inc. announced a joint research collaboration with Dana-Farber Cancer Institute and Harvard Medical School to characterize anti-tumor T cell responses in melanoma patients. This collaboration extends the use of the company’s proprietary ATLAS™ platform for the rapid discovery of T cell antigens to cancer immunotherapy approaches. [Genocea Biosciences, Inc.] Press Release
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