Volume 2.07 | Feb 25

Human Immunology News 2.07 February 25, 2014
Human Immunology News
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Researchers Have Identified a Novel Immunological Mechanism of Great Importance for Vaccine Development
Researchers have discovered the presence of a novel subtype of innate lymphoid cells in human spleen essential for the production of antibodies. This discovery clears the path to the identification of novel strategies to develop more efficient vaccines against encapsulated bacteria, considered highly virulent. [Press release from EurekAlert! discussing online prepublication in Nature Immunology] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia
Scientists report on 16 patients with relapsed or refractory B cell acute lymphoblastic leukemia that they treated with autologous T cells expressing the 19-28z chimeric antigen receptor (CAR) specific to the CD19 antigen. [Sci Transl Med] Abstract | Press Release

Circulating Giant Macrophages as a Potential Biomarker of Solid Tumors
Using precision microfilters under low-flow conditions, investigators isolated circulating cancer-associated macrophage-like cells (CAMLs) from the peripheral blood of patients with breast, pancreatic, or prostate cancer. CAMLs, which are not found in healthy individuals, were found to express epithelial, monocytic, and endothelial protein markers and were observed bound to circulating tumor cells in circulation. [Proc Natl Acad Sci USA] Abstract

Decreased Expression of miR-146a and miR-155 Contributes to an Abnormal Treg Phenotype in Patients with Rheumatoid Arthritis
Scientists investigated microRNA (miR)-146a and miR-155 expression in regulatory T cells (Tregs) of patients with rheumatoid arthritis and their possible impact on Treg function and disease activity. [Ann Rheum Dis] Abstract

IL-27 in Human Secondary Lymphoid Organs Attracts Myeloid Dendritic Cells and Impairs HLA Class I-Restricted Antigen Presentation
Findings highlight novel mechanisms underlying the immunosuppressive activity of IL-27, suggesting that this cytokine may function as a homeostatic cytokine in secondary lymphoid organs by limiting duration and/or intensity of ongoing adaptive immune responses. [J Immunol] Abstract

Expression of B7-H3, a Potential Factor of Tumor Immune Evasion in Combination with the Number of Regulatory T Cells, Affects against Recurrence-Free Survival in Breast Cancer Patients
Investigators demonstrated that expression of B7-H3 on tumor cells and the number of regulatory T cells in the tumor microenvironment independently affected prognosis in breast cancer patients. [Ann Surg Oncol]
Full Article

Angiopoietin-1 Upregulates De Novo Expression of Interleukin (Il)-1β and Il1-Ra, and the Exclusive Release of Il1-Ra from Human Neutrophils
Scientists hypothesized that angiopoietin (Ang)1 and Ang2 could modulate inflammatory signals in neutrophils, a possibility they explored through a gene-based assay looking at changes in the mRNA expression of 84 inflammatory cytokines and their receptors. [PLoS One] Full Article

Donor-Derived CD4+/CCR7+ T-Cell Partial Selective Depletion Does Not Alter Acquired Anti-Infective Immunity
The authors investigated in vitro the impact of partially selective CD4+/chemokine receptor 7 (CCR7)+ T lymphocytes on acquired anti-infective immune response in ten donors who underwent G-CSF-primed PBSC collection. [Bone Marrow Transpl] Abstract

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Challenges and Responses in Human Vaccine Development
Reverse and structural vaccinology have revealed novel antigen candidates and molecular immunology has led to the formulation of promising adjuvants. Gene expression profiles and immune parameters in patients, vaccinees and healthy controls have formed the basis for biosignatures that will provide guidelines for future vaccine design. [Curr Opin Immunol] Full Article

Manipulating Immune Cells for Adoptive Immunotherapy of Cancer
The authors present a brief overview of T cell adoptive cell transfer followed by a review of approaches using alternate lymphocyte subsets and other leukocytes including neutrophils, macrophages and eosinophils. [Curr Opin Immunol] Abstract

Visit our reviews page to see a complete list of reviews in the human immunology research field.

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California Stem Cell Announces U.S. FDA Approval of Phase II Cancer Stem Cell Clinical Trial for Ovarian Cancer
California Stem Cell, Inc. announced that the U.S. Food and Drug Administration (FDA) has approved the company’s application to begin a Phase II clinical trial exploring the potential of a patient-specific cancer immunotherapy in women with Stage III or IV ovarian, fallopian tube or primary peritoneal cancer. [California Stem Cell, Inc.] Press Release

Biothera Presents Phase II Data to International Association for the Study of Lung Cancer
Biothera presented results of its Phase IIb clinical trial in non-small cell lung cancer to top clinicians and scientists at the invitation-only International Association for the Study of Lung Cancer meeting on targeted therapies. Biothera’s Imprime PGG® is a Phase III cancer immunotherapy drug that engages and directs immune cells to recognize and kill cancer. [Biothera, the immune health company] Press Release

Novartis Expands Cancer Immunotherapy Research Program with Acquisition of CoStim
Novartis announced that it is broadening its cancer immunotherapy research program with the acquisition of CoStim Pharmaceuticals Inc., a privately held biotechnology company focused on harnessing the immune system to eliminate immune-blocking signals from cancer. [Novartis AG] Press Release

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National Institutes of Health (United States)

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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW The 2014 Innate Immunity Summit
November 10-12, 2014
London, United Kingdom

Visit our events page to see a complete list of events in the human immunology community.
NEW Postdoctoral Fellow Position – Examining the Impact of the Neonatal Immune System on Perinatal Brain Injury (University of Gothenburg)

Assistant/Associate Professors – Allergic Inflammation and Sensory Neurobiology (North Carolina State University College of Veterinary Medicine)

Research Assistant – Adaptive Immune Proliferation (Cambridge Institute for Medical Research)

Postdoctoral Position – Epigenetic Regulation of Interleukin-12 Family Members (Université Libre de Bruxelles)

PhD Student Position – Molecular Immunology (Institute for Research in Biomedicine)

Postdoctoral Position – Epigenetic Regulation of Interleukin-12 Family Members (Université Libre de Bruxelles)

Postdoctoral Position – Allergy and Immunology (University of Southern California)

Associate Professor – B Cell Immunologist (Institute of Human Virology at the University of Maryland School of Medicine)

PhD Research Position – Immune Tolerance and Autoimmunity (Weizmann Institute of Science)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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