Differential Effects of Fingolimod on B-Cell Populations in Multiple Sclerosis
Scientists analyzed blood samples from nine fingolimod-treated and 19 control patients with multiple sclerosis by flow cytometry, to determine the frequencies and activation states of naive B cells, memory B cells, and plasmablasts. The frequencies of each B-cell population in peripheral blood mononuclear cells were greatly reduced two weeks after starting fingolimod treatment. [Mult Scler]
Abstract
TIRC7 and HLA-DR Axis Contributes to Inflammation in Multiple Sclerosis
TIRC7 was expressed in brain-infiltrating lymphocytes and strongly correlated with disease activity in multiple sclerosis (MS). TIRC7 expression was reduced in T cells and induced in B cells in peripheral blood lymphocytes obtained from MS patients. [Mult Scler]
Abstract
Increased TTS Expression in Patients with Rheumatoid Arthritis
Scientists studied the imbalance expressions of indoleamine 2,3-dioxygenase (IDO) and tryptophanyl-tRNA synthetase (TTS) with rheumatoid arthritis patients. The expressions of IDO and TTS were analyzed by real-time quantitative polymerase chain reaction and flow cytometry in peripheral blood mononuclear cells. [Clin Exp Med]
Abstract
Targeting the Fc Receptor in Autoimmune Disease
The authors discuss the nature of different Fc receptors and the various mechanisms of their involvement in initiating and modulating immunocyte functions and their biological consequences. [Expert Opin Ther Targets]
Abstract
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INDUSTRY NEWS
A*STAR, NUS and NUH Join Forces to Understand Immune Erosion in Elderly
A*STAR’s Singapore Immunology Network signed a three-year partnership with the National University of Singapore (NUS), National University Hospital (NUH) and Sanofi Pasteur to embark on a Phase IV clinical trial to understand age-related loss of immunity, known as immunosenescence, in elderly. [A*STAR]
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