Volume 2.05 | Feb 11

Human Immunology News 2.05 February 11, 2014
Human Immunology News
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Increased Production of Retinoic Acid by Intestinal Macrophages Contributes to Their Inflammatory Phenotype in Patients with Crohn’s Disease
The role of retinoic acid (RA) in human intestinal inflammation is unclear. Researchers investigated which antigen presenting cells produce RA in the human intestine and whether RA generation is reduced in Crohn’s disease. [Gastroenterology] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
IL-9 Regulates Allergen-Specific T-Helper-1 Responses in Allergic Contact Dermatitis
Researchers hypothesized that IL-9 plays a role in human allergic contact dermatitis. To investigate this hypothesis, skin biopsy specimens of positive patch test sites from non-atopic patients were assayed using qPCR and immunohistochemistry. [J Invest Dermatol] Abstract

Comprehensive Immunophenotyping of Cerebrospinal Fluid Cells in Patients with Neuroimmunological Diseases
Investigators performed unbiased, comprehensive immunophenotyping of cerebrospinal fluid and blood leukocytes in 221 subjects referred for the diagnostic work-up of neuroimmunological disorders to obtain insight about disease-specific phenotypes of intrathecal immune responses. [J Immunol] Abstract

The Intramembrane Proteases Signal-Peptide-Peptidase-Like 2a and b (SPPL2a/b) Have Distinct Functions In Vivo
The authors suggested that pharmacological modulation of SPPL2a may represent a novel approach to deplete B cells in autoimmune disorders. With regard to reported overlapping substrate spectra of SPPL2a and its close homologue SPPL2b, they investigated the role of SPPL2b in CD74 N-terminal fragment proteolysis and its impact on B and dendritic cell homeostasis. [Mol Cell Biol] Abstract

Broad Requirement for Terminal Sialic Acid Residues and FcγRIIB for the Preventive and Therapeutic Activity of Intravenous Immunoglobulins In Vivo
Investigators used four independent in vivo model systems of autoantibody-mediated autoimmune disease to identify a common pathway explaining intravenous immunoglobulin activity under therapeutic conditions in vivo. [Eur J Immunol] Abstract

Specific Contactin N-Glycans Are Implicated in Neurofascin Binding and Autoimmune Targeting in Peripheral Neuropathies
Scientists mapped the molecular determinants of Contactin targeted by the autoantibodies. In three patients, immunoreactivity was directed against the Ig domains of Contactin and was dependent on N-glycans. [J Biol Chem] Abstract

Exploring Necrotizing Autoimmune Myopathies with a Novel Immunoassay for Anti-3-Hydroxy-3-Methyl-Glutaryl-CoA Reductase Autoantibodies
Anti-3-hydroxy-3-methyl-glutaryl-CoA reductase levels were assayed in 150 patients with suspicion of necrotizing autoimmune myopathies, 142 controls with different inflammatory/autoimmune diseases and 100 healthy donors. [Arthritis Res Ther] Abstract | Full Article

Estrogen Upregulates IL-21 Production by CD4+ T Lymphocytes in Patients with Systemic Lupus Erythematosus
Peripheral blood was obtained from 22 Systemic lupus erythematosus (SLE) patients and 16 healthy controls. Expression levels of interleukin-21 (IL-21) and its receptor in serum, peripheral blood mononuclear cells (PBMCs), and CD4+ T cells were higher in SLE patients than in healthy controls. [Immunology] Abstract

Differential Expression Pattern of MicroRNAs in CD4+ and CD19+ Cells from Asymptomatic Patients with Systemic Lupus Erythematosus
A screening of the expression of 377 microRNAs was performed in human CD4+ and CD19+ cells isolated from the peripheral blood by using a TaqMan Human MicroRNA Array. Validation of differential expression pattern of those was performed using TaqMan assays in these cell populations obtained from a larger cohort of patients and controls. [Lupus] Abstract

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Anticytokine Autoantibody-Associated Immunodeficiency
Anticytokine autoantibodies are an emerging mechanism of disease in previously healthy adults. Patients with these syndromes demonstrate a unique infectious phenotype associated with neutralizing autoantibodies that target a specific cytokine. This review focuses on the current understanding, both clinically and mechanistically, of anticytokine autoantibody-associated immunodeficiency. [Annu Rev Immunol] Abstract

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Merck Enters Strategic Collaborations with Amgen, Incyte and Pfizer to Evaluate Novel Combination Anti-Cancer Regimens with MK-3475
Merck announced it has signed three separate clinical collaboration agreements, through subsidiaries, with Amgen Inc., Incyte Corporation and Pfizer Inc. to evaluate novel combination regimens with MK-3475, Merck’s investigational anti-PD-1 immunotherapy. [Merck] Press Release

NeoStem Expands Treg International Patent Portfolio with Granting of Patent in Japan
NeoStem, Inc. announced the expansion of intellectual property protection surrounding the Company’s T-regulatory cell (Treg) program with the grant of Japanese Patent Number 5409827 titled “Methods for the Isolation and Expansion of Cord Blood Derived T Regulatory Cells.” This grant further expands the scope and reach of NeoStem’s Treg patent estate internationally. [NeoStem, Inc.] Press Release

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NEW Immunogenicity
July 14-15, 2014
London, United Kingdom

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NEW Research Assistant – Adaptive Immune Proliferation (Cambridge Institute for Medical Research)

NEW Postdoctoral Position – Epigenetic Regulation of Interleukin-12 Family Members (Université Libre de Bruxelles)

PhD Student Position – Molecular Immunology (Institute for Research in Biomedicine)

PhD Studentship – Beta-Cell ER Stress as Driver for Immune Activation in Early Type 1 Diabetes (KU Leuven)

Postdoctoral Position – Epigenetic Regulation of Interleukin-12 Family Members (Université Libre de Bruxelles)

Postdoctoral Position – Allergy and Immunology (University of Southern California)

Associate Professor – B Cell Immunologist (Institute of Human Virology at the University of Maryland School of Medicine)

PhD Research Position – Immune Tolerance and Autoimmunity (Weizmann Institute of Science)

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