Volume 2.04 | Feb 4

Human Immunology News 2.04 February 4, 2014
Human Immunology News
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DNA of Peanut-Allergic Kids Changes with Immune Therapy, Study Finds
Treating a peanut allergy with oral immunotherapy changes the DNA of the patient’s immune cells, according to researchers. The DNA change could serve as the basis for a simple blood test to monitor the long-term effectiveness of the allergy therapy. [Press release from Stanford School of Medicine discussing online prepublication in the Journal of Allergy and Clinical Immunology] Press Release | Abstract
Free Sample: The Only Kit to Isolate Th17 Cells Without Cell Activation
PUBLICATIONS (Ranked by impact factor of the journal)
Identification by Digital Immunohistochemistry of Intratumoral Changes of Immune Infiltrates after Vaccine in the Absence of Modifications of PBMC Immune Cell Subsets
31 phenotypes of peripheral blood mononuclear cells (PBMCs) were analyzed pre- and post-vaccination as well as the functions of PBMC regulatory T cell (Treg) and natural killer cells. A trend was observed in decreases in serum prostate-specific antigen with the reduction of circulating Tregs post-vaccination. [Int J Cancer] Abstract

Allergen-Specific Th2 Responses in Young Children Precede Sensitization Later in Life
Investigators hypothesized that allergen-specific Th2-cell responses can be detected preceding sensitization. Therefore, peripheral blood mononuclear cells of nonsensitized, ‘not-yet’ sensitized or sensitized children were cultured with highly purified allergens. Cytokine levels in supernatant were determined using multiplex assay and GATA3 expression by flow cytometry. [Allergy] Abstract

Cell Contact-Dependent Priming and Fc Interaction with CD32+ Immune Cells Contribute to the TGN1412-Triggered Cytokine Response
TGN1412 treatment of T cells isolated from high-density preculture-PBMCs induced moderate cytokine responses, which upon additional anti-IgG crosslinking were significantly boosted. Moreover, coincubation of TGN1412-treated T cells with B cells expressing the intermediate affinity Fcγ receptor IIB, or coincubation with Fcγ receptor IIB (CD32B)+ transfectants, resulted in robust T cell activation. [J Immunol] Abstract

T Cell Receptor-Mediated Activation Is a Potent Inducer of Macroautophagy in Human CD8+CD28+ T Cells but Not in CD8+CD28 T Cells
The authors investigated autophagy in CD8+CD28+ and CD8+CD28 T cells following T cell receptor (TCR) engagement. They demonstrated that TCR-mediated activation led to a potent induction of autophagy in CD8+CD28+ T cells which was accompanied by an increased activity of the mammalian target of rapamycin complex 1. [Exp Gerontol] Abstract

HLA Restriction of Carbamazepine-Specific T-Cell Clones from an HLA-A*31:01-Positive Hypersensitive Patient
Researchers showed that HLA-A*31:01+ restricted the activation of carbamazepine-specific CD8+ T-cells, which provides an immunological basis for the genetic association. [Chem Res Toxicol] Abstract

Studying IFN-Gamma, IL-17 and FOXP3 in Pediatric Lupus Nephritis
Scientists studied the cytokines secreted by the inflammatory T cell subgroups (IFN-γ and IL-17) and FOXP3 expression in lupus nephritis and analyzed associations with clinical and histopathological parameters. [Pediatr Nephrol] Abstract

APL-2, an Altered Peptide Ligand Derived from Heat-Shock Protein 60, Induces Interleukin-10 in Peripheral Blood Mononuclear Cell Derived from Juvenile Idiopathic Arthritis Patients and Downregulates the Inflammatory Response in Collagen-Induced Arthritis Model
Scientists aimed to evaluate the potentialities of two altered peptide ligands derived from human heat-shock protein 60, an autoantigen involved in the pathogenesis of autoimmune arthritis, in juvenile idiopathic arthritis patients. [Clin Exp Med] Abstract

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On the Relationship between Human Papilloma Virus Vaccine and Autoimmune Diseases
The authors analyze and review comprehensively all case reports and studies dealing with either the onset of an autoimmune disease in vaccinated subject or the safety in patients with autoimmune diseases to define the role of the human papilloma virus vaccines in these diseases and hence its safety. [Autoimmun Rev] Abstract

Interplay of Infections, Autoimmunity, and Immunosuppression in Systemic Lupus Erythematosus
Strategies to prevent infection, including vaccines, prophylactic antibiotic therapies, toll-like receptor antagonism, and antioxidant treatment that may decrease disease burden and improve quality of life in lupus patients are discussed. [Int Rev Immunol] Abstract

Visit our reviews page to see a complete list of reviews in the human immunology research field.

Strategies to Inhibit GvHD While Sparing the Graft-Versus-Tumor Response: Finding the Sweet Spot
Stem Cell Research May Aid Quest to Repair Damaged Immunity
A major research initiative could pave the way for new stem cell therapies for people with damaged immune systems. It aims to develop stem cell therapies that can boost the immune system by repairing the thymus, an organ in the body located next to the heart that produces important immune cells. [MRC Centre for Regenerative Medicine] Press Release

Ablynx Announces Worldwide Cancer Immunotherapy Discovery Collaboration and Licensing Agreement with Merck
Ablynx announced that the company has entered into a second research collaboration and licensing agreement with a subsidiary of Merck & Co. This new exclusive collaboration and licensing agreement is focused on the discovery and development of several predefined Nanobody candidates directed toward so called “immune checkpoint modulators,” proteins believed to provide potential targets for the development of cancer immunotherapies, a rapidly emerging approach to the treatment of a wide range of cancer types. [Ablynx]
Press Release

Stem Cell Agency’s Grants to UCLA Help Set Stage for Revolutionary Medicine
Scientists from University of California, Los Angeles’ (UCLA’s) Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research were awarded grants totaling more than $3.5 million by California’s stem cell agency for their ongoing efforts to advance revolutionary stem cell science in medicine. [University of California, Los Angeles] Press Release

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NEW 3rd International Conference on Immune Tolerance 2014
September 28-30, 2014
Amsterdam, Netherlands

Visit our events page to see a complete list of events in the human immunology community.
NEW PhD Student Position – Molecular Immunology (Institute for Research in Biomedicine)

NEW Lab Technologist – Human Pluripotent Stem Cells (STEMCELL Technologies Inc.)

PhD Studentship – Beta-Cell ER Stress as Driver for Immune Activation in Early Type 1 Diabetes (KU Leuven)

Postdoctoral Position – Epigenetic Regulation of Interleukin-12 Family Members (Université Libre de Bruxelles)

Postdoctoral Position – Allergy and Immunology (University of Southern California)

Senior Scientist – Immuno-Oncology; In Vivo Pharmacology (Genentech, Inc.)

Associate Professor – B Cell Immunologist (Institute of Human Virology at the University of Maryland School of Medicine)

Senior Scientist – Molecular Biology (immatics biotechnologies GmbH)

PhD Research Position – Immune Tolerance and Autoimmunity (Weizmann Institute of Science)

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