|PUBLICATIONS (Ranked by impact factor of the journal)|
Clonal Heterogeneity of Thymic B Cells from Early-Onset Myasthenia Gravis Patients with Antibodies against the Acetylcholine Receptor|
Using immortalization with Epstein-Barr Virus and Toll-like receptor 9 activation, the authors isolated and characterized monoclonal B cell lines from five myasthenia gravis (MG) patients and eight controls. Only 2 of 570 immortalized B cell clones from MG patients produced antibodies against the antibodies against the acetylcholine receptor (AChR) (both clones were from the same patient), suggesting that AChR-specific B cells are not enriched in the thymus. [J Autoimmun]
The Immune Phenotype May Relate to Cancer Development in Kidney Transplant Recipients
High regulatory T-cell (Treg) numbers predict recurrent cutaneous squamous cell carcinoma in kidney transplant recipients, and the Treg immune phenotype may identify kidney transplant recipients at risk of developing squamous cell carcinoma and/or solid-organ cancer. To investigate this, a total of 116 kidney transplant recipients, of whom 65 had current or past cancer, were immune-phenotyped and followed up prospectively for a median of 15 months. [Kidney Int]
Cytokine Effects Induced by the Human Autoallergen α-NAC
Alpha-chain of the nascent polypeptide-associated complex (α-NAC) has been shown before to induce T cell proliferation and secretion of IFN-γ. To elucidate the immune modulating functions α-NAC may exert, the authors analyzed its effects on cytokine transcription and secretion in peripheral blood mononuclear cells, monocytes and CD4+ T cells. [J Invest Dermatol]
Biomarker Evaluation of Face Transplant Rejection: Association of Donor T Cells with Target Cell Injury
A series of 113 sequential biopsies of full facial transplants provides findings of potential translational significance as well as biological insights that could prompt reexamination of conventional paradigms of effector pathways in skin allograft rejection. [Modern Pathol]
Abstract | Press Release
Human Mesenchymal Stromal Cells Transiently Increase Cytokine Production by Activated T Cells before Suppressing T-Cell Proliferation: Effect of Interferon-γ and Tumor Necrosis Factor-α Stimulation
Investigators compared the dynamic action of unprimed and interferon-γ plus tumor necrosis factor-α-pretreated human bone marrow-derived mesenchymal stromal cells on resting or activated T cells. [Cytotherapy]
Targeting IL-6 Signaling in Early Rheumatoid Arthritis Is Followed by Th1 and Th17 Suppression and Th2 Expansion
Scientists investigated the in vitro and ex-vivo effect of IL-6 inhibition on the balance between Th1, Th2, Th17 and Treg cells. The percentages of Th1, Th2, Th17 and Treg cells were analyzed by flow cytometry in the peripheral blood mononuclear cells obtained from controls and from rheumatoid arthritis patients at the time of first evaluation and just before the third TCZ infusion. [Clin Exp Rheumatol]
Neural Progenitor Cells from Human Induced Pluripotent Stem Cells Generated Less Autogenous Immune Response
Through co-culture with autogenous peripheral blood mononuclear cells (PBMCs), researchers showed that both somatic cells and induced pluripotent stem cell-derived neural progenitor cells do not stimulate significant autogenous PBMC proliferation. However, a significant immune reaction was detected when these cells were co-cultured with allogenous PBMCs. [Sci China Life Sci]
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