|PUBLICATIONS (Ranked by impact factor of the journal)|
Characterization of CD4 and CD8 T Cell Responses in MuSK Myasthenia Gravis|
The authors aimed to characterize T cell responses in patients with muscle specific tyrosine kinase myasthenia gravis (MuSK MG). Intracellular production of IFN-gamma, TNF-alpha, IL-2, IL-17, and IL-21 by CD4+ and CD8+ T cells was measured by polychromatic flow cytometry in peripheral blood samples from 11 Musk MG patients and 10 healthy controls. [J Autoimmun]
The SOCS3-Independent Expression of IDO2 Supports the Homeostatic Generation of T Regulatory Cells by Human Dendritic Cells
Investigators found a different pattern of expression and regulation between IDO1 and IDO2 in human circulating dendritic cells (DCs). At the protein level, IDO1 is expressed only in circulating myeloid DCs (mDCs) and is modulated by PGE2, whereas IDO2 is expressed in both mDCs and plasmacytoid DCs and is not modulated by PGE2. [J Immunol]
Neutrophil-Mediated IFN Activation in the Bone Marrow Alters B Cell Development in Human and Murine Systemic Lupus Erythematosus
Researchers report the presence of IFN activation in systemic lupus erythematosus bone marrow (BM), as measured by an IFN gene signature, increased IFN regulated chemokines, and direct production of IFN by BM-resident cells, associated with profound changes in B cell development. [J Immunol]
Role of Regulatory B Cells in Chronic Intestinal Inflammation: Association with Pathogenesis of Crohn’s Disease
Scientists investigated interleukin-10 production in B cells from patients with inflammatory bowel diseases and immunoregulatory functions of regulatory B cells in experimental colitis mouse models. [Inflamm Bowel Dis]
Bruton’s Tyrosine Kinase Regulates TLR9 but Not TLR7 Signaling in Human Plasmacytoid Dendritic Cells
Investigators identified the Bruton’s tyrosine kinase (Btk) as an important player for TLR9 but not TLR7 signaling in human plasmacytoid dendritic cells (PDCs). Blocking Btk using a specific inhibitor leads to the reduction of all TLR9-induced responses in PDCs, including cytokine production and expression of costimulatory molecules, while this has no impact on the TLR7 response. [Eur J Immunol]
Targeting the Programmed Cell Death 1: Programmed Cell Death Ligand 1 Pathway Reverses T Cell Exhaustion in Patients with Sepsis
Researchers tested the ability of anti-programmed cell death 1 (PD-1) and anti-programmed cell death ligand 1 (PD-L1) antibodies to prevent apoptosis and improve lymphocyte function in septic patients. Lymphocytes from septic patients produced decreased interferon-gamma and interleukin-2 and had increased CD8 T cell expression of PD-1 and decreased PD-L1 expression compared to non-septic patients. [Crit Care]
Abstract | Full Article
Changes of Th17/Tc17 and Th17/Treg Cells in Endometrial Carcinoma
Scientists assessed the expression of interleukin (IL)-17 and Foxp3 in the peripheral blood of endometrial carcinoma patients and healthy controls by flow cytometry to determine the relative numbers of T helper 17 (Th17), T cytotoxic 17 (Tc17) and regulatory T (Treg) cells. The frequencies of Th17, Tc17 and Treg cells, as well as the serum level of IL-10, were significantly elevated in endometrial carcinoma patients compared to healthy controls. [Gynecol Oncol]
Selective Activation of Human Dendritic Cells by OM-85 through a NF-kB and MAPK Dependent Pathway
The authors investigated the impact of OM-85 stimulation on human dendritic cell (DC) functions. They showed that OM-85 selectively induced NF-kB and MAPK activation in human DC with no detectable action on the interferon regulatory factor pathway. [PLoS One]
Anti-Melanoma Activity of T Cells Redirected with a TCR-Like Chimeric Antigen Receptor
A TCR-like chimeric receptor, specific for the melanoma-related gp100/HLA-A2 complex was created by joining a TCR-like antibody GPA7 with the endodomains of CD28 and CD3-ζ chain. This TCR-like CAR, GPA7-28z, was subsequently introduced into human T cells. Retargeted T cells expressing GPA7-28z could exhibit efficient cytotoxic activities against human melanoma cells in vitro in the context with HLA-A2. [Sci Rep]
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Dendritic Cells as Targets or Therapeutics in Rheumatic Autoimmune Disease|
This review covers recent advances in the field of dendritic cells as targets or therapeutics in rheumatic autoimmune disease. Key themes include the phenotypic and functional characterization, lineage relationships and transcription factors involved in the development of the various dendritic cell subsets. [Curr Opin Rheumatol]
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