Volume 1.25 | Sep 3

Human Immunology News 1.25 September 3, 2013
Human Immunology News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Increased Th17-Inducing Activity of CD14+ CD163low Myeloid Cells in Intestinal Lamina Propria of Patients with Crohn’s Disease
Scientists investigated whether human intestinal lamina propria cells induce development of T-helper (Th)17 cells and whether these have a role in pathogenesis of Crohn’s disease. [Gastroenterology] Abstract
A New System for High-Throughput Cell Isolation Directly from Whole Blood
 
PUBLICATIONS (Ranked by impact factor of the journal)
Macrophage-Derived IL-33 Is a Critical Factor for Placental Growth
IL-33 was detected in the culture supernatants of human placental and decidual macrophages, identifying them as a major source of secreted IL-33 in the uteroplacental unit. [J Immunol] Abstract

The Systemic Immune Network in Recent Onset Type 1 Diabetes: Central Role of Interleukin-1 Receptor Antagonist (DIATOR Trial)
Researchers hypothesized that the systemic immune milieu in recent-onset type 1 diabetes is associated with residual beta cell function and other metabolic patient characteristics. [PLoS One] Full Article

IL7RA Haplotype-Associated Alterations in Cellular Immune Function and Gene Expression Patterns in Multiple Sclerosis
Soluble IL-7RA (sIL-7RA) protein and mRNA levels vary among the four common IL7RA haplotypes. Scientists showed and confirmed that protective haplotype carriers have three times lower sIL-7RA serum levels than the other three haplotypes. High sIL-7RA concentrations significantly decrease IL-7-mediated STAT5 phosphorylation in CD4+ T cells. [Genes Immun] Abstract

Increased Levels of Interleukin 34 in Serum and Synovial Fluid Are Associated with Rheumatoid Factor and Anticyclic Citrullinated Peptide Antibody Titers in Patients with Rheumatoid Arthritis
To identify the significance of interleukin 34 (IL-34) in rheumatoid arthritis (RA), the IL-34 concentration was measured in serum and synovial fluid (SF). IL-34 concentrations were measured in serum from patients with RA, patients with osteoarthritis (OA), and controls, and in SF isolated from patients with RA or OA. [J Rheumatol] Abstract

Association of +3179G/A Insulin-Like Growth Factor-1 Receptor Polymorphism and Insulin-Like Growth Factor-1 Serum Level with Systemic Lupus Erythematosus
The authors compared +3179G/A insulin-like growth factor (IGF)-1R genotype distribution in 148 systemic lupus erythematosus (SLE) patients with a group of 240 healthy donors. They also investigated serum IGF-1 levels in SLE patients and healthy controls in an association to genotype. [Lupus] Abstract

Immune Response to Intrathecal Enzyme Replacement Therapy in Mucopolysaccharidosis I Patients
Researchers studied the immune response to intrathecal recombinant human-L-iduronidase (rhIDU) in mucopolysaccharidosis I subjects with spinal cord compression who had been previously treated with intravenous rhIDU. [Pediatr Res] Abstract

Pre- and Perinatal Characteristics and Breast Milk Immune Markers
Maternal allergy and gestational exposures can alter the concentration of Type-1/Type-2/T-regulatory markers in breast milk. The authors tested whether maternal risk factors are related to breast milk immune markers. [Pediatr Res] Abstract

Analysis of Cytokines and Chemokines Produced by Whole Blood, Peripheral Mononuclear and Polymorphonuclear Cells
Investigators aimed to determine the cytokine response of whole blood, peripheral blood mononuclear cells and polymorphonuclear cells after stimulation with lipopolysaccharide. They used a multiplex analysis to determine a difference in cytokine secretion patterns. [J Immunol Methods] Abstract

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REVIEWS
Macrophages in Atherosclerosis: A Dynamic Balance
The authors summarize recently identified pro- and anti-inflammatory pathways that link lipid and inflammation biology with the retention of macrophages in plaques, as well as factors that have the potential to promote their egress from these sites. [Nat Rev Immunol] Abstract

Nuclear Factor Kappa B (NF-κB) in Multiple Sclerosis Pathology
This review summarizes recent evidence clarifying the role of NF-κB in the different cell compartments contributing to multiple sclerosis (MS) pathology and its implications for the development of therapeutic strategies for the treatment of MS and other demyelinating pathologies of the central nervous system. [Trends Mol Med] Abstract

The Preventive Role of Type 2 NKT Cells in the Development of Type 1 Diabetes
This review points to the importance of immunoregulation by type 2 natural killer T (NKT) cells in preventing the development of type 1 diabetes (T1D) and highlights the induction of tolerogenic dendritic cells as a likely mechanism. The possible therapeutic role of type 1 and type 2 NKT cells are evaluated and future experiments concerning type 2 NKT cells and T1D are proposed. [APMIS] Abstract

Visit our reviews page to see a complete list of reviews in the human immunology research field.

Attend World Vaccine Congress 2013 in Lille, France
 
INDUSTRY NEWS
MedImmune Strengthens Immune-Mediated Cancer Therapy Portfolio with Acquisition of Amplimmune
AstraZeneca announced that MedImmune, its global biologics research and development arm, has entered into a definitive agreement to acquire Amplimmune, a privately-held, Maryland, US-based biologics company focused on developing novel therapeutics in cancer immunology. [AstraZeneca] Press Release

European Commission Approves Genzyme’s Once-Daily, Oral Multiple Sclerosis Treatment Aubagio® (Teriflunomide)
Genzyme announced that the European Commission has granted marketing authorization for Aubagio® 14 mg, a once-daily, oral therapy indicated for the treatment of adult patients with relapsing remitting multiple sclerosis. [Genzyme Corporation] Press Release

Stem Cell Agency Awards More than $40 Million in New Research Grants
The agency’s governing Board the Independent Citizens Oversight Committee approved $40 million in funding for researchers at 10 institutions including Stanford, UCLA, UC San Diego, Human BioMolecular Research Institute, Cedars-Sinai Medical Center, The Gladstone Institutes, Sanford-Burnham Medical Research Institute, The Salk Institute, Numerate, Inc. and UC Irvine as part of its Early Translational IV Research awards. [California Institute for Regenerative Medicine] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Society for Immunotherapy of Cancer
November 7-10, 2013
National Harbor, United States

NEW Autoimmunity Congress Asia (ACA) 2013
November 20-22, 2013
Hong Kong, Hong Kong

Visit our events page to see a complete list of events in the human immunology community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Fellow – Immunity & Inflammation Program (Vaccine & Gene Institute of Florida)

Postdoctoral Scientist – Melanoma Biology (Gustave Roussy Cancer Institute)

Postdoctoral Position – Elucidation of the Role of Specific Ubiquitin-Binding Proteins in Regulating NFKB Signaling in Innate Immune Cells (AstraZeneca)

Postdoctoral Position – Innate Immune Signaling in the Developing Intestine (University of Connecticut Health Center)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Tenure-Track Position – Cell Biologist (McGill University)

Postdoctoral Fellow – Role of the IL-23/IL-17 Axis in Inflammatory Arthritis (UC Davis Medical Center)

PhD Research Position – Immune Tolerance and Autoimmunity (Weizmann Institute of Science)


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